Background: Transcendental meditation (TM) is a stress reduction technique that can potentially lower blood pressure (BP) safely. The American Heart Association recommends that TM may be considered in clinical practice.
Objective: To provide an overview of all systematic reviews and meta-analyses of TM on BP for evidence-informed clinical decision making.
Method: Systematic searches of PubMed, EBSCOhost, Cochrane Library, Web of Science, Embase, and PsycINFO for all systematic reviews and/or meta-analyses of randomized controlled trials (RCTs) with TM as an intervention, and outcome measures include systolic BP (SBP) and diastolic BP (DBP). Qualitative and quantitative data were synthesized. The methodological quality of the selected reviews was assessed using the AMSTAR checklist.
Results: Eight systematic reviews and meta-analyses are included. Among them is an Agency for Healthcare Research and Quality report, a Cochrane systematic review, 4 independent reviews, and 2 reviews from a TM related institution. The quality of most of the included reviews is fair with a mean score of 5.75/11 on the AMSTAR scale. Overall, there exists a clear trend of increasing evidence over the years supporting the efficacy of TM in lowering BP. However, some conflicting findings remain across reviews and potential risk of bias exists in many of the RCTs included in these reviews.
Conclusion: Practising TM may potentially reduce the SBP by ∼4mm Hg and DBP by ∼2mm Hg. Such effect is comparable with other lifestyle interventions such as weight-loss diet and exercise. Further evidence from long-term well-designed RCTs conducted by independent researchers is needed.
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http://dx.doi.org/10.1016/j.ctim.2017.07.008 | DOI Listing |
Front Psychol
January 2025
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Background: Fatigue is a prevalent issue among cancer patients. Cognitive behavioral therapy (CBT) is an individualized intervention that empowers patients and caregivers to actively participate in the treatment process. A recent systematic review and meta-analysis examined the impact of CBT on fatigue in cancer patients.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of Critical Care Medicine, Qilu Hospital, Shandong University, Qingdao, China.
Objective: To investigate the potential and evolving trends in fluid management for patients with sepsis, utilizing a bibliometric approach.
Methods: Scholarly articles pertaining to fluid therapy for sepsis patients were extracted from the Web of Science (WoS) database as of June 1, 2024. The R software package, "Bibliometrix," was utilized to scrutinize the primary bibliometric attributes and to construct a three-field plot to illustrate the relationships among institutions, nations, and keywords.
Front Med (Lausanne)
January 2025
Department Three of Orthopedics/Plastic Surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Objective: This study systematically evaluated the efficacy of programmed death 1 (PD-1) inhibitors combined with chemotherapy for advanced esophageal cancer (EC).
Methods: PubMed, Embase, Web of Science, Scopus, and Cochrane Library were searched to identify related randomized controlled trials (RCTs).
Results: Seven RCTs involving 4,363 participants were included.
Front Immunol
January 2025
Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, characterized by frequent recurrence, metastasis, and poor survival outcomes despite chemotherapy-based treatments. This study aims to investigate the mechanisms by which Traditional Chinese Medicine (TCM) modulates the tumor immune microenvironment in TNBC, utilizing CiteSpace and bioinformatics analysis.
Methods: We employed CiteSpace to analyze treatment hotspots and key TCM formulations, followed by bioinformatics analysis to identify the main active components, targets, associated pathways, and their clinical implications in TNBC treatment.
Front Immunol
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macao, Macao SAR, China.
Background: Telitacicept, a new biological agent, was approved in China for treating systemic lupus erythematosus (SLE) in 2021. Its optimal dosing for treating SLE remains unclear. Therefore, the aim of this meta-analysis is to evaluate the efficacy and safety of various telitacicept doses in SLE treatment.
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