Approach to Membranous Lupus Nephritis: A Survey of Pediatric Nephrologists and Pediatric Rheumatologists.

Alexis Boneparth Suhas M Radhakrishna Larry A Greenbaum Eric Yen Daryl M Okamura Jennifer C Cooper Sherene Mason Deborah M Levy Sangeeta D Sule Paul T Jensen Cagri Yildirim-Toruner Stacy P Ardoin Scott E Wenderfer

J Rheumatol

Columbia University Medical Center, New York, New York; Rady Children's Hospital, University of California San Diego, San Diego; University of California Los Angeles, Los Angeles; University of California San Francisco, San Francisco, California; Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia; Seattle Children's Hospital Research Institute, University of Washington, Seattle, Washington; Connecticut Children's Hospital, University of Connecticut, Hartford, Connecticut; Johns Hopkins University, Baltimore, Maryland; Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio; Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA; Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Published: November 2017

Objective: To describe treatment practices for childhood pure membranous lupus nephritis (MLN).

Methods: Survey study of Childhood Arthritis and Rheumatology Research Alliance and American Society of Pediatric Nephrology members.

Results: There were 117 respondents who completed the survey (60 pediatric nephrologists, 57 pediatric rheumatologists). Steroids and nonsteroid immunosuppression (NSI) were routinely used by the majority for MLN. Mycophenolate mofetil was the favored initial NSI. Nephrologists used steroids (60% vs 93%) and NSI (53% vs 87%) less often than did rheumatologists for MLN without nephrotic syndrome (NS).

Conclusion: Pediatric rheumatologists and nephrologists both recommend steroids and NSI for children with MLN, with or without NS.

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http://dx.doi.org/10.3899/jrheum.170502	DOI Listing

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