Misregulation of extracellular Ca can indicate bone-related pathologies. New, noninvasive tools are required to image Ca fluxes and fluorine magnetic resonance imaging (F-MRI) is uniquely suited to this challenge. Here, we present three, highly fluorinated peptide amphiphiles that self-assemble into nanoribbons in buffered saline and demonstrate these nanostructures can be programmed to change F-NMR signal intensity as a function of Ca concentration. We determined these nanostructures show significant reduction in F-NMR signal as nanoribbon width increases in response to Ca, corresponding to F-MR image intensity reduction. Thus, these peptide amphiphiles can be used to quantitatively image biologically relevant Ca concentrations.
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| http://dx.doi.org/10.1021/acsami.7b07828 | DOI Listing |
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