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Three-year outcome of a very young severe uncontrolled preschool wheezers cohort, a real-life study.
Respir Med
December 2024
Univ Rouen Normandie, Dynamicure INSERM UMR 1311, CHU Rouen, Department of Paediatrics and Adolescent Medicine, F-76000, Rouen, France.
Preschool wheeze is a public health issue. Disease control can be difficult to obtain in this population, in which no biologic therapy is indicated. We studied the evolution of severe preschool wheezers in real-life and identified the factors leading to no-control.
View Article and Find Full Text PDFSmoking-related interstitial lung disease: A narrative review.
Chron Respir Dis
October 2024
Department of Pneumology, Santiago de Compostela University Hospital Complex, Santiago de Compostela, Spain.
Although smoking-related interstitial lung diseases (SR-ILD) are a relatively rare group of entities, they are a relevant public health problem of growing importance, both because they affect young adults and because of their increasing prevalence in recent years due to increased tobacco consumption. In patients who smoke and have non-specific respiratory symptoms, SR-ILD should be ruled out, a term that encompasses a group of different entities in which the basis for diagnosis is the smoking history together with compatible respiratory functional findings, radiology and/or histology. An association has been established between tobacco smoke and a group of diseases that include respiratory bronchiolitis-associated interstitial lung disease (2%-3% of all ILD), desquamative interstitial pneumonia (<1%), Langerhans cell histiocytosis (3%-5%) and acute eosinophilic pneumonia.
View Article and Find Full Text PDFCord blood granulocyte levels are associated with severe bronchiolitis in the first year of life.
Clin Transl Immunology
September 2024
Asthma and Breathing Program, Hunter Medical Research Institute The University of Newcastle Newcastle NSW Australia.
Article Synopsis
- Bronchiolitis is a major reason infants are hospitalized in their first year and is more common in babies born to mothers with asthma.
- The study analyzed cord blood granulocytes (eosinophils and neutrophils) from 89 infants, examining their relationship to bronchiolitis hospitalization over the first year.
- Results showed higher eosinophil levels in cord blood were linked to increased risk of bronchiolitis hospitalization, indicating that early immune cell profiles may affect vulnerability to this condition later on.
Myeloperoxidase-ANCA IgG induces different forms of small vessel vasculitis based on type of synergistic immune stimuli.
Kidney Int
November 2024
Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; University of North Carolina Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:
Anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis has diverse patterns of injury including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Necrotizing and crescentic glomerulonephritis (NCGN) occurs in all syndromes and as renal limited vasculitis (RLV). Single-dose intravenous ANCA IgG-specific for mouse myeloperoxidase (MPO) causes RLV in mice.
View Article and Find Full Text PDFAndrographolide sulfonate downregulation of TLR3-TRIF and amelioration of airway inflammation caused by respiratory syncytial virus infection.
J Thorac Dis
July 2024
Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Background: Andrographolide sulfonate (Andro-S), a traditional Chinese medicine, is commonly used to treat pediatric respiratory tract infections in China. However, its therapeutic effects in infections caused by respiratory syncytial virus (RSV) have not been reported. We thus aimed to investigate the therapeutic effects of Andro-S using a mouse model of RSV infection-induced airway inflammation.
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