The present study aimed to investigate how bats protect their brain in a hypothermic situation. Formosan leaf-nosed bats (Hipposideros terasensis) were used in this study and treated under three conditions: room temperature (25±1°C), low temperature (4±1°C), and hibernation. The reactive oxygen species (ROS) levels in the blood and apoptosis-related proteins in the brain tissue were assessed and then compared among those bats under three conditions. Our results showed that the blood ROS levels of bats treated under conditions of low temperature and hibernation were significantly reduced compared with bats treated under the condition of room temperature. Both immunohistochemistry and immunoblotting expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain tissue of bats treated under the condition of hibernation were significantly reduced compared with those bats treated under conditions of room temperature and low temperature. Thus, we suggested that bats can protect the brain in cold environment by reducing blood ROS levels and decreasing expressions of hypoxia, inflammation, and apoptosis-related proteins in the brain. Possible protection mechanisms involved in hypothermic adaptations need to be further clarified.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/WNR.0000000000000856 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Medical Ultrasound Application Beyond Diagnosis: Insights From Ultrasound Sensing and Biological Response.
Biotechnol J
December 2024
Department of Ultrasound Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Ultrasound (US) can easily penetrate media with excellent spatial precision corresponding to its wavelength. Naturally, US plays a pivotal role in the echolocation abilities of certain mammals such as bats and dolphins. In addition, medical US generated by transducers interact with tissues via delivering ultrasonic energy in the modes of heat generation, exertion of acoustic radiation force (ARF), and acoustic cavitation.
View Article and Find Full Text PDFPRACTICAL AND QUICK WORK FLOW FOR ORCHIECTOMY OF 338 BATS () FOR POPULATION MANAGEMENT WITH INJECTABLE ANESTHESIA.
J Zoo Wildl Med
December 2024
Veterinary Clinic Vienna Zoo, 1130 Vienna, Austria.
In captivity, neotropical Seba's short-tailed bats () (Chiroptera: Phyllostomidae) reproduce readily, and contraception can constitute an opportunity to prevent uncontrolled reproduction, which can lead to overpopulation as well as inbreeding. The authors developed a safe and efficient work flow, anesthetic, and surgical castration protocol for the reproductive control of a captive population of more than 500 bats housed at the rainforest house at the Vienna Zoo, Austria. An anesthetic protocol using 0.
View Article and Find Full Text PDFA Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies.
J Vis Exp
November 2024
US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services;
Oral vaccination of wildlife against rabies via the distribution of vaccine-laden baits is used widely as a management tool in Europe and North America. Over the past several decades, successful programs have targeted important reservoirs, including coyotes, foxes, raccoon dogs, and raccoons, for prevention and control. However, other species (e.
View Article and Find Full Text PDFReflector-guided localization compared with wire-guided localization for non-palpable breast cancer resection: organizational impacts and costs analysis.
J Gynecol Obstet Hum Reprod
February 2025
Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Gynecological Oncology Surgery Department, 20 Rue Leblanc, Paris 75015, France; Environmental Toxicity, Therapeutic Targets, Cellular Signaling and Biomarkers, T3S, INSERM UMR-S 1124, Paris F-75006, France.
Background: Wire-guided localization (WGL) for non-palpable breast cancer lesions has drawbacks like wire migration, localization difficulties, and logistical challenges. Wireless methods, such as reflector-guided localization (RGL), address these issues and are compatible with breast MRI. This study evaluates the organizational and cost impacts of RGL compared to WGL.
View Article and Find Full Text PDFRare bleeding disorders (RBDs) represent 3 to 5% of congenital bleeding disorders and are primarily inherited in an autosomal recessive manner, with increased prevalence in consanguineous populations. Clinically, RBDs can be accompanied by mild to severe bleeding episodes, often assessed using bleeding assessment tools (BATs) such as the International Society on Thrombosis and Hemostasis (ISTH)-BAT. However, the correlation between bleeding severity and coagulation factor activity levels remains inconsistent.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!