AI Article Synopsis
- The study aimed to explore the link between serum 25-hydroxyvitamin D levels and hormonal/metabolic profiles in women with and without Polycystic Ovary Syndrome (PCOS).
- A total of 48 normal-weight and 36 overweight women with PCOS, along with 56 normal-weight controls, were involved, with blood samples taken during the early follicular phase of their menstrual cycles.
- Results showed that both PCOS groups had lower levels of 25-OH D compared to controls, with negative correlations to waist measurements and free testosterone, indicating that PCOS is related to low vitamin D levels.
Article Abstract
Objective: The main aim of this study was to determine the association of serum 25-hydroxyvitamin D (25-OH D) levels with hormonal, clinical and metabolic profile in patients with and without Polycystic ovary syndrome (PCOS).
Materials And Methods: Forty-eight normal-weight (body mass index (BMI) of 19-24.99 kg/m) women with PCOS, 36 overweight (BMI of 25-29.9 kg/m) women with PCOS and 56 normal-weight controls participated in the study. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 am after an overnight fast. Circulating concentrations of 25-OH D, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, TSH, free testosterone, dehydroepiandrosterone sulphate (DHEA-SO4), 17-hydroxyprogesterone, sex hormone-binding globulin (SHBG), fasting insulin, fasting glucose, and lipid profile were assessed.
Results: Normal weight (BMI 19-24.99 kg/m) and overweight (BMI 25-29.99 kg/m) women with PCOS were compared with normal-weight controls and lower 25-OH D levels were found in both PCOS groups (p<0.05 and p<0.01, respectively 25-OH D significantly negatively correlated with waist circumference (WC), waist-to-hip ratio (WHR), free testosterone and modified Ferriman-Gallwey scores, however, there was a positive correlation between 25-OH D and SHBG levels (p<0.05).
Conclusion: Our findings suggest that PCOS is associated with hypovitaminosis D.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558399 | PMC |
| http://dx.doi.org/10.4274/tjod.76148 | DOI Listing |
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