Unlike Support Vector Machine (SVM), Multiple Kernel Learning (MKL) allows datasets to be free to choose the useful kernels based on their distribution characteristics rather than a precise one. It has been shown in the literature that MKL holds superior recognition accuracy compared with SVM, however, at the expense of time consuming computations. This creates analytical and computational difficulties in solving MKL algorithms. To overcome this issue, we first develop a novel kernel approximation approach for MKL and then propose an efficient Low-Rank MKL (LR-MKL) algorithm by using the Low-Rank Representation (LRR). It is well-acknowledged that LRR can reduce dimension while retaining the data features under a global low-rank constraint. Furthermore, we redesign the binary-class MKL as the multiclass MKL based on pairwise strategy. Finally, the recognition effect and efficiency of LR-MKL are verified on the datasets Yale, ORL, LSVT, and Digit. Experimental results show that the proposed LR-MKL algorithm is an efficient kernel weights allocation method in MKL and boosts the performance of MKL largely.
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http://dx.doi.org/10.1155/2017/3678487 | DOI Listing |
J Chem Inf Model
December 2024
School of Information Engineering, Xijing Univerity, Xi'an 710123, China.
Numerous studies show that circular RNA (circRNA) functions as a sponge for microRNA (miRNA), significantly regulating gene expression by interacting with miRNA, which in turn affects the progression of human diseases. Traditional experimental approaches for investigating circRNA-miRNA interactions (CMI) are both time-consuming and costly, making computational methods a valuable alternative. Hence, we propose a computational model for predicting CMI, leveraging a ybrid multmodal nework and igher-order nighborhood infomation (Hither-CMI).
View Article and Find Full Text PDFNat Rev Drug Discov
December 2024
BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Regulatory T (T) cells are a suppressive subset of CD4 T cells that maintain immune homeostasis and restrain inflammation. Three decades after their discovery, the promise of strategies to harness T cells for therapy has never been stronger. Multiple clinical trials seeking to enhance endogenous T cells or deliver them as a cell-based therapy have been performed and hint at signs of success, as well as to important limitations and unanswered questions.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Department of Radiology, The Affiliated Children's Hospital Of Xiangya School of Medicine, Hunan Children's Hospital, Central South University, Changsha, China.
This study aims to investigate the value of basal ganglia and limbic/paralimbic networks alteration in identifying preschool children with ASD and normal controls using diffusion basis spectrum imaging (DBSI). DBSI data from 31 patients with ASD and 30 NC were collected in Hunan Children's Hospital. All data were imported into the post-processing server.
View Article and Find Full Text PDFGenes (Basel)
October 2024
Department of Pathology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia.
Bethlem myopathy is a rare genetic disease caused by a variant mapped to 21q22, which harbors the collagen type VI alpha 2 chain and collagen type VI alpha 1 chain ( genes, and 2q37, which harbors the collagen type VI alpha 3 chain () gene. Disease onset can occur at any age, and the symptoms are related to those of muscular dystrophy. Since Bethlem myopathy is a rare disease, no previous studies have been conducted in Arab countries, including Saudi Arabia.
View Article and Find Full Text PDFBioData Min
November 2024
Institut de Mathématiques de Toulouse, UMR5219, CNRS, UPS, Université de Toulouse, Cedex 9, Toulouse, 31062, France.
Background: Advances in high-throughput technologies have originated an ever-increasing availability of omics datasets. The integration of multiple heterogeneous data sources is currently an issue for biology and bioinformatics. Multiple kernel learning (MKL) has shown to be a flexible and valid approach to consider the diverse nature of multi-omics inputs, despite being an underused tool in genomic data mining.
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