Objective: The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with polycystic ovary syndrome (PCOS).
Patients And Methods: We studied 372 women with PCOS according to the NIH criteria. 232 age- and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patients with PCOS were classified into two groups: with adrenal hyperandrogenism (PCOS-AH, = 108) and without adrenal hyperandrogenism (PCOS-NAH, = 264). Anthropometric measurements were recorded. Fasting plasma glucose, insulin, lipid profile, sex hormone-binding globulin (SHBG) and androgen (TT, Δ4A, DHEA-S) concentrations were assessed. Free androgen index (FAI) and homeostatic model assessment-insulin resistance (HOMA-IR) index were calculated.
Results: Women with PCOS-AH were younger than PCOS-NAH ( < 0.001), but did not differ in the degree and type of obesity. No differences were found in HOMA-IR, total cholesterol, HDL-c, LDL-c and triglyceride concentrations (in all comparisons, > 0.05). These metabolic parameters did not differ between the two groups even after correction for age. Women with PCOS-AH had lower SHBG (29.2 ± 13.8 vs 32.4 ± 11.8 nmol/L, = 0.025) and higher TT (1.0 ± 0.2 vs 0.8 ± 0.4 ng/mL, = 0.05) and Δ4A (3.9 ± 1.2 vs 3.4 ± 1.0 ng/mL, = 0.007) concentrations, as well as FAI (14.1 ± 8.0 vs 10.2 ± 5.0, < 0.001). These results were confirmed by a multiple regression analysis model in which adrenal hyperandrogenism was negatively associated with age ( < 0.001) and SHBG concentrations ( = 0.02), but not with any metabolic parameter.
Conclusions: Women with PCOS and adrenal hyperandrogenism do not exhibit any deterioration in insulin resistance and lipid profile despite the higher degree of total androgens.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640571 | PMC |
| http://dx.doi.org/10.1530/EC-17-0239 | DOI Listing |
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