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Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach.
Pharmaceutics
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Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, Indonesia.
The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines.
View Article and Find Full Text PDFTenodesis in Flail Foot: A New Surgical Technique.
Arch Bone Jt Surg
January 2024
Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Flail foot is a condition characterized by a significant weakness in ankle dorsiflexion, resulting in limited or no active mobility in the ankle. To address this issue, we described a novel approach called tenodesis, which has been developed for ankle joint stabilization. This technique utilizes the patient's tendons to minimize potential complications.
View Article and Find Full Text PDFConjugated phthalocyanine-based framework as artificial SEI for over 400 Wh kg lithium-metal battery.
Natl Sci Rev
February 2025
School of Chemistry, South China Normal University, Guangzhou 510006, China.
High-voltage lithium-metal batteries (HVLMBs) are appealing candidates for next-generation high-energy rechargeable batteries, but their practical applications are still limited by the severe capacity degradation, attributed to the poor interfacial stability and compatibility between the electrode and the electrolyte. In this work, a 2D conjugated phthalocyanine framework (CPF) containing single atoms (SAs) of cobalt (CoSAs-CPF) is developed as a novel artificial solid-electrolyte interphase (SEI) in which a large amount of charge is transferred to the CPF skeleton due to the Lewis acid activity of the Co metal sites and the strong electron-absorbing property of the cyano group (-CN), greatly enhancing the adsorption of the Li and regulating the Li distribution toward dendrite-free LMBs, which are superior to most of the reported SEI membranes. As a result, the Li||Li symmetrical cell with CoSAs-CPF-modified Li anodes (CoSAs-CPF@Li) exhibits a low polarization with an area capacity of 1.
View Article and Find Full Text PDFEmerging role of ultrasound guided interventional management in cervicogenic headache.
J Pak Med Assoc
January 2025
Quetta Institute of Medical Sciences, Quetta, Pakistan.
The objective of this mini review is to discuss the role of musculoskeletal ultrasound (MSK US) in identification and treatment of pain generators in cervical spine in patients presenting with cervicogenic headache (CEH). CEH is a secondary headache arising from cervical nociceptive structures emerging from facet joints, intervertebral discs, nerves, muscles, fascia and ligaments. It presents a complex challenge in clinical management.
View Article and Find Full Text PDFFinger reconstruction with vascularized partial osteo-onycho-cutaneous great toe transfer: It's time to address the donor site.
J Hand Microsurg
March 2025
Department of Plastic, Cosmetic, Hand and Microsurgery, Sir Ganga Ram Hospital, Room No. 2325, 3rd Floor, SSRB Building, New Delhi, 110060, India.
Free vascularized partial great toe is a composite tissue consisting of the osteo-onycho-cutaneous component with neurovascular pedicle and is used for reconstructing amputated fingers at different levels. The half-big-toe nail flap represents that while it provides a good match and functional results; it also conserves the donor foot by having all five toes intact. The aesthetic and functional aspects of the amputated thumbs and fingers can be worked upon and significantly improved.
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