AI Article Synopsis
- - The study investigates the antifungal properties of Drimenol and its synthetic derivatives against Botrytis cinerea, a significant plant pathogen.
- - The results indicate that all tested compounds have an impact on the growth of B. cinerea, with Drimenol being particularly effective, suggesting that the double bond in its structure is crucial for its antifungal activity.
- - The research also explores the mechanism of action behind drimenol's antifungal effects by examining factors like membrane integrity, reactive oxygen species production, and the expression of specific genes involved in its activity.
Article Abstract
The aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for drimenol. For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC values of 80, 92, 80 and 314ppm, respectively. These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80ppm of drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed.
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| http://dx.doi.org/10.1016/j.pestbp.2016.11.006 | DOI Listing |
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