Significant elevation of antiviral activity of strictinin from Pu'er tea after thermal degradation to ellagic acid and gallic acid.

J Food Drug Anal

Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan; Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan. Electronic address:

Published: March 2015

Compared with abundant catechins, strictinin is a minor constituent in teas and has been demonstrated to possess inhibitory potency on influenza virus. In this study, strictinin was found as the major phenolic compound in Pu'er teas produced from leaves and buds of wild trees. Due to its thermal instability, strictinin, in tea infusion or in an isolated form, was completely decomposed to ellagic acid and gallic acid after being autoclaved for 7 minutes. A plaque reduction assay was employed to compare the relative inhibitory potency between strictinin and its thermally degraded products against human influenza virus A/Puerto Rico/8/34. The results showed that the antiviral activity of ellagic acid regardless of the presence or absence of gallic acid was significantly higher than that of strictinin. Thermal degradation of strictinin to ellagic acid and gallic acid seems to be beneficial for the preparation of Pu'er teas in terms of enhancing antiviral activity.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351740PMC
http://dx.doi.org/10.1016/j.jfda.2014.07.007DOI Listing

Publication Analysis

Top Keywords

ellagic acid
16
gallic acid
16
antiviral activity
12
acid gallic
12
thermal degradation
8
acid
8
inhibitory potency
8
influenza virus
8
pu'er teas
8
strictinin
7

Similar Publications

Red raspberries, valued for their nutrients and bioactive compounds, have broad uses in processing and healthy products. However, limited comprehensive research focused on the comparison of phenolic compounds of red raspberry, especially species cultivated in Northeast China, has been reported. This study aimed to conduct a thorough investigation of 24 red raspberry varieties in Northeast China for the first time, evaluating their phenolic compounds and antioxidant capacities.

View Article and Find Full Text PDF

Design, Synthesis, and Anti-infective Effect Against Candida albicans of A New Urolithin Derivative.

Chem Biodivers

December 2024

Changzhou University - Wujin Campus: Changzhou University, School of Pharmacy & School of Biological and Food Engineerin, No. 21, Middle Lake Road, Wujin District, Changzhou City, Jiangsu Province, 213164, Changzhou, CHINA.

Deep mucosal and organ infections caused by the infestation of Candida albicans(C.albicans) in immunocompromised patients represent a significant cause of mortality in hospitalised patients. The rise in fungal resistance is a consequence of the overuse of antibiotics.

View Article and Find Full Text PDF

Cancer stem cells (CSCs) are responsible for chemoresistance and tumor relapse in many solid malignancies, including lung and ovarian cancer. Ellagic acid (EA), a natural polyphenol, exhibits anticancer effects on various human malignancies. However, its impact and mechanism of action on cancer stem-like cells (CSLCs) are only partially understood.

View Article and Find Full Text PDF

Turning agro-food waste into resources: Exploring the antioxidant effects of bioactive compounds bioaccessibility from digested jabuticaba tree leaf extract.

Food Chem

December 2024

In vitro and in vivo Nutritional and Toxicological Analysis Lab, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil.; Bioactivity & Applications Laboratory, Department of Biological Sciences, Faculty of Science and Engineering, School of Natural Sciences, University of Limerick, Limerick, Ireland.. Electronic address:

The jabuticaba tree leaf, considered an agro-food by-product or waste, was evaluated as a potential unconventional ingredient of bioactive compounds. Its hydroalcoholic extracts were assessed for the phenolic chemical profile by LC-QQQ-MS and antioxidant capacity pre- and post-gastrointestinal digestion (i.e.

View Article and Find Full Text PDF

Oxidative stress has been implicated as a causative factor for the development and progression of osteoporosis(OP). Ellagic acid (EA), a natural polyphenol, presents anti-oxidative and anti-inflammatory properties. However, EA's role and molecular mechanism in osteoblasts have not yet been elucidated.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!