R3.8 is a psychrotolerant bacterial strain isolated from a soil sample obtained at Rothera Point, Adelaide Island, close to the Antarctic Peninsula. Strain R3.8 was sequenced in order to help discover potential cold active enzymes with biotechnological applications. Genome analysis identified various cold adaptation genes including some coding for anti-freeze proteins and cold-shock proteins, genes involved in bioremediation of xenobiotic compounds including naphthalene, and genes with chitinolytic and -acetylglucosamine utilization properties and also plant-growth-influencing properties. In this genome report, we present a complete genome sequence of strain R3.8 and its annotation data, which will facilitate exploitation of potential novel cold-active enzymes.
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http://dx.doi.org/10.1186/s40793-017-0264-0 | DOI Listing |
Pediatr Cardiol
March 2024
Duke Department of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Anthracyclines are effective chemotherapeutics used in approximately 60% of pediatric cancer cases but have a well-documented risk of cardiotoxicity. Existing cardiotoxicity risk calculators do not include cardiovascular risk factors present at the time of diagnosis. The goal of this study is to leverage the advanced sensitivity of strain echocardiography to identify pre-existing risk factors for early subclinical cardiac dysfunction among anthracycline-exposed pediatric patients.
View Article and Find Full Text PDFMicrob Drug Resist
February 2024
Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Methicillin-resistant (MRSA) is a major infectious disease pathogen, and its molecular epidemiological profile has been changing. In this study, a total of 279 MRSA isolates were collected from patients with bloodstream infection (BSI) in Hokkaido, northern main island of Japan, for a 2-year period from August 2019 to July 2021. CC5 (ST5/ST764)-MRSA-IIa (SCC-IIa) (47%, = 132) and CC1 (ST1/ST2725/ST2764)-MRSA-IVa (42%, = 116) were found to be major lineages, with CC8-MRSA-IVa being lower prevalence (5%, = 13).
View Article and Find Full Text PDFCirc Res
October 2023
Division of Cardiology, Department of Medicine, College of Medicine (S.P., F.J.G.-G., K.S.L., A.A., A.E.C., A.S., J.G., S.-G.O., D. Darbar, B.M.W., M.D.M.), University of Illinois at Chicago.
Background: Atrial fibrillation (AF)-the most common sustained cardiac arrhythmia-increases thromboembolic stroke risk 5-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contractile function remain unknown. We tested the hypothesis that increased expression of PPP1R12C (protein phosphatase 1 regulatory subunit 12C)-the PP1 (protein phosphatase 1) regulatory subunit targeting MLC2a (atrial myosin light chain 2)-causes hypophosphorylation of MLC2a and results in atrial hypocontractility.
View Article and Find Full Text PDFInt J Mol Sci
September 2023
School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Vanillin holds significant importance as a flavoring agent in various industries, including food, pharmaceuticals, and cosmetics. The CoA-dependent pathway for the biosynthesis of vanillin from ferulic acid involved feruloyl-CoA synthase (Fcs) and enoyl-CoA hydratase/lyase (Ech). In this research, the Fcs and Ech were derived from sp.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
June 2023
Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA.
Background: Smooth muscle cell (SMC) phenotypic reprogramming toward a mixed synthetic-proteolytic state is a central feature of aortic root aneurysm in Marfan syndrome (MFS). Previous work identified as a potential mediator of SMC plasticity in MFS.
Methods: MFS () mouse strains with an inducible vascular SMC fluorescent reporter () with or without SMC-specific deletion of exons 2 to 3 () were generated.
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