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Febrile Ulceronecrotic Mucha-Habermann Disease Associated With Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature.
Am J Dermatopathol
April 2024
Department of Dermatology, Columbia University Irving Medical Center, New York, NY.
Article Synopsis
- Mucha-Habermann disease (MHD) is an inflammatory skin condition with symptoms resembling cutaneous T-cell lymphoma, while its severe variant, febrile ulceronecrotic MHD (FUMHD), presents with systemic symptoms and ulcers.
- A case study of a 21-year-old woman showed atypical lymphomatoid features of FUMHD alongside hemophagocytic lymphohistiocytosis (HLH), leading to significant clinical findings and a biopsy that indicated atypical CD8 + lymphocyte infiltration.
- Treatment using etoposide and dexamethasone resulted in rapid improvement of her symptoms, with the patient's skin lesions healing over time and confirming the MHD diagnosis; she has remained
[Severe systemic vasculitis induced by ibrutinib].
Rev Med Interne
January 2024
Dermatologie, CHD Vendée, Les Oudairies, boulevard Stéphane-Moreau, 85925 La-Roche-sur-Yon, France.
Introduction: The specific cutaneous toxicity of Bruton's tyrosine kinase inhibitors is poorly described. We report a case of severe systemic vasculitis induced by ibrutinib.
Observation: A 73-year-old woman with chronic lymphocytic leukemia was treated with ibrutinib.
A primary small cell neuroendocrine carcinoma (SCNC) of the oral cavity (cheek mucosa): Description of a case report.
Oral Oncol
February 2023
Division of Medical Oncology, "CHR Metz-Thionville", 1 Allée du Château, 57085 Ars-Laquenexy, France. Electronic address:
Background: Small cell neuroendocrine carcinoma (SCNC) of the oral cavity is a poorly differentiated, high-grade and very aggressive tumor with a poor prognosis.
Case Description: A 64-year-old, Caucasian, smoker man consulted for an ulcero-necrotic, exophytic, lesion of the right retromolar trigone. Haed&neck CT scan showed a right tonsillar tumor lesion.
Blood Serum Zonulin in Colorectal Cancer, Autoimmune Bowel Diseases, and Irritable Bowel Syndrome.
Bull Exp Biol Med
July 2022
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Zonulin content in blood serum of patients with colorectal cancer (CRC; n=152; 30-84 years) and patients with large bowel adenomas (n=32; 39-82 years) was measured by standardized kit IDK Zonulin ELISA (Immundiagnostik AG). The healthy control group (n=50) comprised volunteers (27 women, 23 men; 25-68 years); pathological control group (n=84) - patients (55 women, 29 men;18-84 years) with irritable bowel syndrome (n=29), Crohn's disease (n=5), and ulcero-necrotic colitis (n=50). In comparison to healthy control group, the level of zonulin was significantly increased in CRC patients (p<0.
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