AI Article Synopsis
- A mathematical model for a peroxidase-based optical biosensor was developed using non-linear reaction-diffusion equations focusing on two compartments: an enzyme layer and an outer diffusion layer.
- The digital simulation employed a finite difference technique to analyze the biosensor's performance.
- Results indicated that both substrate concentration and the thickness of the enzyme and diffusion layers significantly affected the biosensor’s response, revealing complex kinetics at low concentrations of peroxidase and hydrogen peroxide.
Article Abstract
The response of a peroxidase-based optical biosensor was modelled digitally.A mathematical model of the optical biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments, an enzyme layerand an outer diffusion layer. The digital simulation was carried out using finite differencetechnique. The influence of the substrate concentration as well as of the thickness of both theenzyme and diffusion layers on the biosensor response was investigated. Calculations showedcomplex kinetics of the biosensor response, especially at low concentrations of the peroxidaseand of the hydrogen peroxide.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965226 | PMC |
| http://dx.doi.org/10.3390/s7112723 | DOI Listing |
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