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Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Transplantation.
Xenotransplantation
January 2025
Division of Cardiac Surgery, Department of Surgery, Children's Hospital of Los Angeles, Los Angeles, California, USA.
Introduction: There is no standard protocol for management of organ preservation for orthotopic, life-sustaining cardiac xenotransplantation, particularly for hearts from pediatric sized donors. Standard techniques and solutions successful in human allotransplantation are not viable. We theorized that a solution commonly used in reparative cardiac surgery in human children would suffice by exploiting the advantages inherent to xenotransplantation, namely the ability to reduce organ ischemic times by co-locating the donor and recipient.
View Article and Find Full Text PDFNuclear Medicine Cerebral Perfusion Studies as an Ancillary Test to Support Evaluation of Brain Death/Death by Neurologic Criteria: Single-Center Experience in Infants, 2005-2022.
Pediatr Crit Care Med
December 2024
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Objective: To describe the use of nuclear medicine cerebral perfusion studies as an ancillary test for brain death/death by neurologic criteria (BD/DNC) in infants aged under 1 year.
Design: Retrospective case series.
Setting: Single-center, quaternary, academic children's hospital in the United States.
Updated information on neuro-prognosticative tools to predict outcomes for patients with hypoxic-ischemic encephalopathy induced by cardiac arrest.
Intractable Rare Dis Res
November 2024
Institute of Neurology, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Hypoxic-ischemic encephalopathy (HIE), caused by cardiac arrest (CA) is a refractory condition in clinical settings. The clinician and family members have to make a hard decision: continue expensive life-sustaining therapy or withdraw the expensive intervention. The core problem lies in "whether this patient can still be awakened and achieve neurological recovery".
View Article and Find Full Text PDFUnderstanding the Best Nutritional Management for Creutzfeldt-Jakob Disease Patients: A Comparison Between East Asian and Western Experiences.
Life (Basel)
November 2024
Department of Public Health and Infectious Disease, University of Rome "Sapienza", 00185 Rome, Italy.
(1) Background: Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disorder caused by the accumulation of an altered prion protein, which usually leads to death within one year after clinical onset. CJD patients usually present with rapid cognitive impairment associated with declines in cerebellar, motor, visual, behavioral, and swallowing functions. Moreover, CJD patients lose their ability to eat and take medications orally very early on in treatment; nevertheless, there are no specific nutritional guidelines for this disease shared worldwide.
View Article and Find Full Text PDFSurvival strategies of Eisenia fetida in antibiotic-contaminated soil based on screening canonical correlation analysis model.
Ecotoxicol Environ Saf
December 2024
College of Resources and Environmental Science, Northeast Agricultural University, Harbin 150030, China. Electronic address:
Soil pollution from antibiotics has become increasingly severe, posing significant environmental and human health threats. Many soil organisms can survive and sustain their roles in maintaining soil ecosystems, even in polluted conditions. Exploring the life-sustaining mechanisms of these organisms in contaminated environments is scientifically significant.
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