Quantitative physiology and elemental composition of Kluyveromyces lactis CBS 2359 during growth on glucose at different specific growth rates.

Antonie Van Leeuwenhoek

Department of Chemical Engineering, Polytechnic School, University of São Paulo, Av. Prof. Luciano Gualberto 380, São Paulo, SP, 05508-010, Brazil.

Published: February 2018

AI Article Synopsis

  • Kluyveromyces lactis is a yeast known for its ability to grow on lactose, making it valuable for both research and industrial applications, especially in protein production.
  • Research has focused on generating quantitative physiological data from chemostat cultivations of the K. lactis CBS 2359 strain under controlled glucose-limiting and aerobic conditions.
  • This data will help compare K. lactis with Saccharomyces cerevisiae and support future studies in metabolic flux analysis and modeling.

Article Abstract

The yeast Kluyveromyces lactis has received attention both from academia and industry due to some important features, such as its capacity to grow in lactose-based media, its safe status, its suitability for large-scale cultivation and for heterologous protein synthesis. It has also been considered as a model organism for genomics and metabolic regulation. Despite this, very few studies were carried out hitherto under strictly controlled conditions, such as those found in a chemostat. Here we report a set of quantitative physiological data generated during chemostat cultivations with the K. lactis CBS 2359 strain, obtained under glucose-limiting and fully aerobic conditions. This dataset serves [corrected] as a basis for the comparison of K. lactis with the model yeast Saccharomyces cerevisiae in terms of their elemental compositions, as well as for future metabolic flux analysis and metabolic modelling studies with K. lactis.

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http://dx.doi.org/10.1007/s10482-017-0940-5DOI Listing

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