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Cross-Generational Impact of Maternal Exposure to Low Level of PM2.5 on Kidney Health.
Am J Nephrol
November 2024
Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, New South Wales, Australia.
Introduction: Inhaled fine and ultrafine particulate matter may affect organs other than the lung, including the kidney. Recent studies have consistently shown the possibility of air pollution in highly polluted countries to be nephrotoxic. However, in countries like Australia, where air quality generally adheres to or remains below the WHO standards, the subtle yet consequential impacts of chronic exposure to seemingly safe levels of traffic PM2.
View Article and Find Full Text PDFUrinary Nephrin: A Potential Biomarker of Early Glomerular Injury in a Cohort of Pregnant Women Attending Routine Antenatal Care Services.
Int J Nephrol
November 2024
College of Public Health, Medical and Veterinary Science, James Cook University, 1 James Cook Drive, Douglas, Townsville, Queensland 4811, Australia.
Glomerular injury may occur during pregnancy as a consequence of systemic disease and pregnancy-related medical complications. While urinary nephrin has been shown to provide early identification of preeclampsia (PE) in high-risk pregnancies, the role of urinary nephrin in determining glomerular injury in pregnant women is yet to be explored. This study aimed to investigate the use of urinary nephrin as a predictor for early glomerular injury in a study conducted at the Townville University Hospital.
View Article and Find Full Text PDFAssociation of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT).
J Perinatol
January 2025
University of Wisconsin, Division of Neonatology, Madison, WI, USA.
Article Synopsis
- Delayed cord clamping (DCC) is a common practice during preterm births, but its effects on kidney health are uncertain.
- A study evaluated DCC against early cord clamping (ECC) in preterm infants, focusing on acute kidney injury (AKI) and kidney function at two years.
- Findings indicated that DCC did not reduce the risk of AKI but was linked to a significantly higher chance of reduced kidney function (eGFR <90 mL/min/1.73m) after two years.
Predictive biomarkers of preeclampsia severity in a low resource setting: Role of red blood cell indices, NLR, and albumin-to-creatinine ratio.
Narra J
August 2024
Department of Obstetrics and Gynecology, McGill University, Montreal, Canada.
Preeclampsia (PE), a serious medical condition with substantial maternal and perinatal implications, poses a significant challenge, particularly in high-incidence countries like Indonesia. Red blood cell (RBC) indices, neutrophil-to-lymphocyte ratio (NLR), and microalbuminuria (albumin-to-creatinine ratio (ACR)) may signal systemic inflammation and endothelial dysfunction, recently recognized as potential indicators for diagnosing and predicting disease severity. The aim of this study was to analyze RBC indices, NLR, and ACR changes in women with PE and their potential for predicting disease severity.
View Article and Find Full Text PDFPreeclampsia: A comprehensive review.
Clin Chim Acta
September 2024
Department of Biochemistry, Shah Abdul Latif University, Khairpur, Sindh, Pakistan. Electronic address:
Preeclampsia (PE) is a life-threatening disease of pregnancy and a prominent cause of neonatal and maternal mortality and morbidity. PE affects approximately 5-10% of pregnancies worldwide, posing significant risks to perinatal and maternal health. It is characterized by a variety of interconnected pathological cascades contributing to the stimulation of intravascular inflammation, oxidative stress (OS), endothelial cell activation, and syncytiotrophoblast stress that converge on a common pathway, ultimately resulting in disease progression.
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