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Homocysteine aggravates intestinal inflammation through promotion of 5-LOX and COX-2 in IBD.
Eur J Med Res
November 2024
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 JiXi Road, Hefei, 230022, Anhui, People's Republic of China.
Article Synopsis
- Homocysteine (Hcy) is a pro-inflammatory molecule that can cause oxidative damage and promote inflammation, especially in vascular cells, but its effects on intestinal inflammation are not well understood.
- Researchers conducted a study with 99 IBD patients and 10 healthy individuals to investigate Hcy's role in increasing inflammatory mediators like LTE4 and PGE2, using both animal models and human cells for testing.
- Results showed higher levels of Hcy, LTE4, and PGE2 in IBD patients, and Hcy significantly upregulated inflammatory markers and pathways in colitis rats, indicating its potential role in exacerbating intestinal inflammation.
Abnormal expression of oxylipins and related synthesizing/signaling pathways in inflammatory bowel diseases.
Prostaglandins Leukot Essent Fatty Acids
March 2024
Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1007, Tunisia; Laboratory of Biochemistry & LR99ES11, Rabta Hospital, Tunis 1007, Tunisia. Electronic address:
We investigated selected oxylipins and related synthesizing/signaling pathways in 28 patients with Crohn's disease (CD), 19 patients with ulcerative colitis (UC), and 39 controls. Plasma and mucosal PUFA/oxylipin profiles were analyzed by LC-MS/MS. mRNA expression of 5, 12 and 15-lipooxygenases, FPR2/ALXR, FFAR4/GPR120, annexin A1, and interleukin-10 were analyzed by qRT-PCR.
View Article and Find Full Text PDFInvolvement of Proinflammatory Arachidonic Acid (ARA) Derivatives in Crohn's Disease (CD) and Ulcerative Colitis (UC).
J Clin Med
March 2022
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, W. Broniewskiego 24, 71-460 Szczecin, Poland.
Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been observed, especially among children and adolescents. Currently, few studies focus on the differentiation of inflammation in IBD subunits, i.e.
View Article and Find Full Text PDFTuft Cells and Their Role in Intestinal Diseases.
Front Immunol
May 2022
Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune responses and relevance for gut diseases, have increased dramatically over the last fifteen years. A key discovery in 2016 of their close connection to helminthic and protozoan infection has further spurred the exploration of these rare chemosensory epithelial cells. Although very sparse in number, tuft cells are now known as important sentinels in the gastrointestinal tract as they monitor intestinal content using succinate as well as sweet and bitter taste receptors.
View Article and Find Full Text PDFBiological drug and drug delivery-mediated immunotherapy.
Acta Pharm Sin B
April 2021
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
The initiation and development of major inflammatory diseases, , cancer, vascular inflammation, and some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these diseases, whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes , poor penetration across biological barriers, and rapid clearance by the reticuloendothelial system. Drug delivery strategies are potent to promote their delivery.
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