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Eradication of HIV-1 latent reservoirs through therapeutic vaccination. | LitMetric

Eradication of HIV-1 latent reservoirs through therapeutic vaccination.

AIDS Res Ther

Department of Microbiology and Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.

Published: September 2017

AI Article Synopsis

  • Combination anti-retroviral therapy is effective at reducing HIV viremia, but HIV-1 is still a lifelong infection needing ongoing management.
  • Recent advancements in HIV cure research draw from new understandings of the infection process and innovative vaccine strategies from other medical fields.
  • The "Kick and Kill" therapy aims to reverse HIV latency and eliminate the virus by activating the immune response alongside anti-retroviral treatments to eradicate infected cells.

Article Abstract

Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic engineering have fueled rapid advancements in HIV cure research. In the last few years, several studies have focused on the development of "Kick and Kill" therapies to reverse HIV latency and kick start viral translational activity. This has been done with the aim that concomitant anti-retroviral treatment and the elicited immune responses will prevent de novo infections while eradicating productively infected cells. In this review, we describe our perspective on HIV cure and the new approaches we are undertaking to eradicate the established pro-viral reservoir.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594457PMC
http://dx.doi.org/10.1186/s12981-017-0177-4DOI Listing

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