Patients with sensorineural hearing loss can recover their hearing using a cochlear implant (CI). However, there is a need to develop next-generation CIs to overcome the limitations of conventional CIs caused by extracorporeal devices. Recently, artificial basilar membranes (ABMs) are actively studied for next-generation CIs. The ABM is an acoustic transducer that mimics the mechanical frequency selectivity of the BM and acoustic-to-electrical energy conversion of hair cells. This paper presents recent progress in biomimetic ABMs. First, the characteristics of frequency selectivity of the ABMs by the trapezoidal membrane and beam array are addressed. Second, to reflect the latest research of energy conversion technologies, ABMs using various piezoelectric materials and triboelectric-based ABMs are discussed. Third, in vivo evaluations of the ABMs in animal models are discussed according to the target position for implantation. Finally, future perspectives of ABM studies for the development of practical hearing devices are discussed.
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http://dx.doi.org/10.1002/adhm.201700674 | DOI Listing |
Int J Numer Method Biomed Eng
January 2025
Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Osaka, Japan.
In a previous study [H. Shintaku et al., Sensors and Actuators A: Physical 158 (2010): 183-192], an artificially developed auditory sensor device showed a frequency selectivity in the range from 6.
View Article and Find Full Text PDFAJNR Am J Neuroradiol
September 2024
From the Department of Radiology (Aakanksha Sriwastwa, Lily Li-Li-Wang, Achala S. Vagal), University of Cincinnati Medical Center, Cincinnati, Ohio, USA; Department of Neurology and Rehabilitation Medicine (Yasmin N. Aziz, Stacie L. Demel), University of Cincinnati Medical Center, Cincinnati, Ohio, USA; University of Cincinnati College of Medicine (Kara Weiss, Robert Buse, Bin Zhang), Cincinnati, Ohio, USA; Division of Biostatistics (Bin Zhang), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Diagnostic Radiology (Arafat Ali), Henry Ford Medical Center, Ann Arbor, Michigan, USA; and Department of Diagnostic Radiology (Sriharsha Voleti), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background And Purpose: Fast, accurate detection of large (LVO) and medium vessel occlusion (MeVO) is critical for triage and management of acute ischemic stroke. Multiple AIbased software products are commercially available. However, their strengths and limitations for detection of vessel occlusion in the context of expanding indications for mechanical thrombectomy are not entirely understood.
View Article and Find Full Text PDFAdv Sci (Weinh)
August 2024
Department of Mechanical Engineering, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of Korea.
A spiral-artificial basilar membrane (S-ABM) sensor is reported that mimics the basilar membrane (BM) of the human cochlea and can detect sound by separating it into 24 sensing channels based on the frequency band. For this, an analytical function is proposed to design the width of the BM so that the frequency bands are linearly located along the length of the BM. To fabricate the S-ABM sensor, a spiral-shaped polyimide film is used as a vibrating membrane, with maximum displacement at locations corresponding to specific frequency bands of sound, and attach piezoelectric sensor modules made of poly(vinylidene fluoride-trifluoroethylene) film on top of the polyimide film to measure the vibration amplitude at each channel location.
View Article and Find Full Text PDFJ Imaging Inform Med
February 2024
Department of Pulmonary and Critical Care, University of Cincinnati Medical Center, Cincinnati, USA.
We previously validated Fibresolve, a machine learning classifier system that non-invasively predicts idiopathic pulmonary fibrosis (IPF) diagnosis. The system incorporates an automated deep learning algorithm that analyzes chest computed tomography (CT) imaging to assess for features associated with idiopathic pulmonary fibrosis. Here, we assess performance in assessment of patterns beyond those that are characteristic features of usual interstitial pneumonia (UIP) pattern.
View Article and Find Full Text PDFQuant Imaging Med Surg
October 2023
Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Background: The combination of computed tomography angiography (CTA) and computed tomography perfusion (CTP) evaluation of cerebral perfusion status and vascular conditions can improve the diagnostic accuracy of infarction, ischemia, and vascular occlusion in stroke patients, as well as a comprehensive assessment of cerebral edema, collateral circulation, and blood perfusion in the lesion area. However, the consequent radiation safety and contrast agent nephropathy have aroused increasing concern. The purpose of this study was to assess the image quality and diagnostic accuracy of CTA images derived from CTP data, and to explore the feasibility of replacing conventional CTA.
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