AI Article Synopsis
- The Hodgkin-Huxley model has been updated to include the physical characteristics of the fluid within the axon, resulting in new partial differential equations.
- Key findings from the model include a conduction velocity of 19.5 m/sec at 18.5°C and a demonstrated sensitivity of conduction velocity to temperature changes between 5°C and 25°C.
- The model also details the physical parameters' behavior in relation to action potentials, including the viscosity of axoplasmic fluid and the longitudinal diffusivity of ions.
Article Abstract
Hodgkin-Huxley model has been reframed to incorporate the physical parameters of fluid inside the axon. The reframed model comprises of set of partial differential equations containing the physical parameters: density, mass fraction of sodium, potassium and chlorine ions, longitudinal diffusivity of ions and rate of additions of ions along with the temperature. Obtained conduction velocity of 19.5m/sec at a temperature of 18.5 degree celcius and conduction velocity dependency on temperature within the range 5 to 25 degree celcius are two important results that strongly validate the proposed model. The behavior of all the physical parameters has been characterized with respect to the action potential. Action potential conduction velocity along with axoplasmic fluid viscosity has been characterized with respect to different temperatures. Longitudinal diffusivity of ions is also quantified.
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| http://dx.doi.org/10.3233/JIN-170029 | DOI Listing |
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