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Zonulopathies as Genetic Disorders of the Extracellular Matrix.
Genes (Basel)
December 2024
Department of Ophthalmology, Southend University Hospital, Southend-on-Sea SS0 0RY, UK.
The zonular fibres are formed primarily of fibrillin-1, a large extracellular matrix (ECM) glycoprotein, and also contain other constituents such as LTBP-2, ADAMTSL6, MFAP-2 and EMILIN-1, amongst others. They are critical for sight, holding the crystalline lens in place and being necessary for accommodation. Zonulopathies refer to conditions in which there is a lack or disruption of zonular support to the lens and may clinically be manifested as ectopia lens (EL)-defined as subluxation of the lens outside of the pupillary plane or frank displacement (dislocation) into the vitreous or anterior segment.
View Article and Find Full Text PDFLong-term outcomes of scleral fixated black diaphragm intraocular lens in eyes with combined aphakia and aniridia.
Eur J Ophthalmol
January 2025
Dept of Vitreoretinal Diseases, Sankara Nethralaya, Chennai, India.
Article Synopsis
- The study evaluated the long-term outcomes of scleral fixation of aniridic black diaphragm intraocular lenses (BDIOL) in 38 eyes affected by aniridia and aphakia due to trauma or congenital conditions.
- After an average follow-up of 28 months, there was a significant improvement in visual acuity, and patients reported reduced glare and photophobia, though some experienced complications like elevated intraocular pressure and corneal decompensation.
- The findings suggest that scleral fixation of BDIOL is an effective solution for patients lacking capsular support, providing good vision quality with a low rate of complications, regardless of prior surgical history.
Nd:YAG Laser Application for the Treatment of Retained Lens Fragment in the Anterior Chamber Following Cataract Surgery.
Turk J Ophthalmol
December 2024
University of Health Sciences Türkiye, Ulucanlar Eye Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye.
Cataract surgery is the most frequently performed surgery worldwide. Although it is an effective surgical treatment option for improving patients' visual acuity, various complications can occur postoperatively. One such complication is the presence of retained lens material in the anterior chamber, which can lead to intraocular inflammation, increased intraocular pressure, corneal edema, and endothelial cell loss.
View Article and Find Full Text PDFClinical spectrum of bilateral microspherophakia and risk factors associated with poor visual outcomes following lensectomy surgery - A multicentric study.
Indian J Ophthalmol
December 2024
The Bodhya Eye Consortium, India.
Purpose: To study the clinical profile of patients with microspherophakia and the factors associated with poor vision following lensectomy surgery.
Methods: A multicenter, retrospective, cross-sectional analysis was conducted from January 2010 to June 2022 on patients diagnosed with microspherophakia.
Results: A total of 102 eyes from 51 patients were enrolled, of whom 24 (47.
Introduction: The aim of our study was to assess the outcome of Gore-Tex sutures in minimally invasive scleral fixation of subluxated posterior chamber intraocular lenses (PCIOLs) and to demonstrate a method for validating the lens position.
Methods: Retrospective study of patients who underwent lasso in-the-bag scleral fixation of a subluxated PCIOL using the snare technique with Gore-Tex suture from 2019 to 2021 in a single tertiary medical center. Functional outcome was analyzed by clinical assessment, and anatomical outcome, by ultrasound biomicroscopy (UBM).
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