AI Article Synopsis
- * In this study, researchers transplanted dissociated testicular tissue into castrated cockerels, which resulted in a significant 300-fold increase in aggregate size compared to traditional testis growth.
- * The transplanted cells successfully restored seminiferous tubule structure and produced both testosterone and motile sperm, demonstrating the strong regenerative capacity of 11-week-old cockerel testicular cells.
Article Abstract
Previous studies have shown that grafted neonatal chicken testicular tissue can develop and produce functional sperm; however, it was unclear whether regenerative processes or proportional growth caused the re-appearance of spermatogenic tissue. We dissociated testicular tissues, performed subcutaneous auto-transplantation of the re-aggregated cells to castrated cockerels, and monitored the post-surgery development of these transplanted aggregates. We found that these transplanted cell aggregates experienced compensatory growth in the form of a 300-fold increase in size, rather than the 30-fold increase observed in normal testis development. Further, these dissociated testicular cell aggregates restored seminiferous tubule structure and were able to produce testosterone and motile sperm. Therefore, we concluded that the dissociated testicular cells from 11-week-old cockerels retained a strong regenerative potential, as they exhibited compensatory growth, restored destroyed structure, and sustained spermatogenesis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735267 | PMC |
| http://dx.doi.org/10.1262/jrd.2017-090 | DOI Listing |
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