Lignanamides with potent antihyperlipidemic activities from the root bark of Lycium chinense.

Fitoterapia

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; Collaborative Innovation Center for Respiratory Disease Diagnosis, Treatment and New Drug Research and Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China. Electronic address:

Published: October 2017

Seven new lignanamides, lyciumamides D-J (1-4 and 9-11), together with nine known analogues (5-8 and 12-16), were isolated from the root bark of Lycium chinense. The structures of the isolated compounds were elucidated on the basis of NMR spectroscopic and HRESIMS data. All isolated compounds were evaluated for antihyperlipidemic activities in HepG2 cells. The primary structure-activity relationships were discussed.

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http://dx.doi.org/10.1016/j.fitote.2017.09.004DOI Listing

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