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Heavy metals: toxicity and human health effects.
Arch Toxicol
January 2025
Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37, Bratislava, Slovakia.
Heavy metals are naturally occurring components of the Earth's crust and persistent environmental pollutants. Human exposure to heavy metals occurs via various pathways, including inhalation of air/dust particles, ingesting contaminated water or soil, or through the food chain. Their bioaccumulation may lead to diverse toxic effects affecting different body tissues and organ systems.
View Article and Find Full Text PDFHeavy metals exposure and Alzheimer's disease: Underlying mechanisms and advancing therapeutic approaches.
Behav Brain Res
January 2025
Biology Department, College of Science and Humanities, Shaqra University, Saudi Arabia. Electronic address:
Heavy metals such as lead, cadmium, mercury, and arsenic are prevalent in the environment due to both natural and anthropogenic sources, leading to significant public health concerns. These heavy metals are known to cause damage to the nervous system, potentially leading to a range of neurological conditions including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and attention-deficit hyperactivity disorder (ADHD). The present study examines the complex relationship between heavy metal exposure and AD, focusing on the underlying mechanisms of toxicity and potential therapeutic approaches.
View Article and Find Full Text PDFAlzheimer's Disease and Circulatory Imbalance of Toxic Heavy Metals: A Systematic Review and Meta-analysis of Clinical Studies.
Biol Trace Elem Res
July 2024
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, 9717853076, Iran.
The role of heavy metals on human health has often been discussed regarding disease pathogenesis and risk factors. Alzheimer's disease (AD), a prevalent neurodegenerative disease, is no exception. We conducted a comprehensive examination to assess the concentrations of lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) in biological samples of AD patients in comparison with a group of individuals without AD, with the objective of our study being to perform a systematic review on this topic.
View Article and Find Full Text PDFRevisiting the focal role of endostatin and environmental factors in Alzheimer's disease.
Environ Sci Pollut Res Int
July 2024
Laboratoire de Chrono-Environnement, UMR CNRS 6249, Université de Bourgogne Franche-Comté, La Bouloie, 25030, Besancon Cedex, France.
Alzheimer's disease (AD) is a condition initiated by the assimilation of β-amyloid plaques (Aβ) and tau tangles, leading to neurodegeneration. It involves frequently cognitive decline as well as memory impairment in patients. Efforts in therapeutic interventions are currently facing challenges in identifying targets within this scaffold that can significantly alter the clinical course for individuals with AD.
View Article and Find Full Text PDFTenecteplase versus alteplase for thrombolysis in patients selected by use of perfusion imaging within 4·5 h of onset of ischaemic stroke (TASTE): a multicentre, randomised, controlled, phase 3 non-inferiority trial.
Lancet Neurol
August 2024
Hunter New England Local Health District, New Lambton Heights, NSW, Australia; Faculty of Medicine, University of Newcastle, Newcastle, NSW, Australia.
Article Synopsis
- The study compared the effectiveness of intravenous tenecteplase and alteplase in treating ischaemic stroke patients identified as having salvageable brain tissue using perfusion imaging, focusing on whether tenecteplase is at least as effective (non-inferior) to alteplase in terms of patient outcomes after 3 months.
- Conducted across 35 hospitals in eight countries, the trial enrolled 680 patients aged 18 and older, who were randomly assigned to receive either tenecteplase or alteplase, with the primary outcome being the rate of patients without disability measured through the modified Rankin Scale.
- The trial was halted early due to positive results
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