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Manganese and Developmental Neurotoxicity. | LitMetric

Manganese and Developmental Neurotoxicity.

Adv Neurobiol

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Viale Europa, 11, 25123, Brescia, Italy.

Published: December 2017

AI Article Synopsis

Article Abstract

Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and executive functions through the involvement of the frontal cortex.Neurodevelopmental disturbances are increasing in the society, and understanding the potential role of environmental determinants is a key for prevention. Therefore, assessing the environmental sources of Mn exposure and the mechanisms of developmental neurotoxicity and defining appropriate biomarkers of exposure and early functional alterations represent key issues to improve and address preventive strategies. These themes will be reviewed in this chapter.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057616PMC
http://dx.doi.org/10.1007/978-3-319-60189-2_2DOI Listing

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