TET proteins in natural and induced differentiation.

Curr Opin Genet Dev

La Jolla Institute, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. Electronic address:

Published: October 2017

The ten-eleven-translocation (TET) proteins oxidize 5-methylcytosine in DNA. Alterations in TET protein function have been linked to cancer, but TETs have also been observed to influence many cell differentiation processes. Here we review recent work assessing the contribution of TET proteins to natural and induced differentiation. Altogether these analyses have helped characterize how TETs and their enzymatic products influence DNA methylation patterns, regulatory element activity, DNA binding protein specificity and gene expression.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033320PMC
http://dx.doi.org/10.1016/j.gde.2017.07.011DOI Listing

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