Intratumor heterogeneity driving therapeutic resistance is a major challenge in cancer management. Recently in Nature, Shlush et al. (2017) provide a tour de force of genomics coupled to functional assays to demonstrate that resistance emerges from a pre-existing subpopulation of acute myeloid leukemia (AML) cells with a stem cell transcription program.
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| http://dx.doi.org/10.1016/j.stem.2017.08.004 | DOI Listing |
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Adaptive evolutionary trajectories in complexity: Transitions between unicellularity and facultative differentiated multicellularity.
Proc Natl Acad Sci U S A
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Department of Mathematics and Mathematical Statistics, Umeå University, Umeå 90187, Sweden.
Multicellularity spans a wide gamut in terms of complexity, from simple clonal clusters of cells to large-scale organisms composed of differentiated cells and tissues. While recent experiments have demonstrated that simple forms of multicellularity can readily evolve in response to different selective pressures, it is unknown if continued exposure to those same selective pressures will result in the evolution of increased multicellular complexity. We use mathematical models to consider the adaptive trajectories of unicellular organisms exposed to periodic bouts of abiotic stress, such as drought or antibiotics.
View Article and Find Full Text PDFSurvival of the fittest: do low vitrified/warmed donor oocyte survival rates reflect the quality of the remaining eggs?
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Shady Grove Fertility, San Diego, California.
Environmental regulation, factor flow, and resource misallocation.
J Environ Manage
January 2025
School of Economics and Management, Guangxi Normal University, Guilin, 541006, China.
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Survival of the fittest? Peak oxygen uptake and all-cause mortality among older adults in Norway.
Prog Cardiovasc Dis
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Cardiac Exercise Research Group (CERG), Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:
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