The Gram-stain-negative, rod-shaped, strictly aerobic, motile bacterial strain, designated YM155, was isolated from a seamount near the Yap Trench in the tropical western Pacific. Phylogenetic analysis based on 16S rRNA gene sequence showed that strain YM155 was related to the genus Thalassotalea and had highest 16S rRNA gene sequence similarities with the type strains of Thalassotalea piscium T202 (97.2 %) and Thalassotalea agariperforans M-M1 (97.2 %). The predominant cellular fatty acids were C17 : 1ω8c, summed feature 3 (composed of iso-C15 : 0 2-OH and/or C16 : 1ω7c) and iso-C16 : 0. Ubiquinone 8 (Q-8) was the respiratory quinone. The polar lipid profile contained phosphatidylglycerol, phosphatidylethanolamine, two unidentified phospholipids and one unidentified lipid. The genomic DNA G+C content of strain YM155 was 36.1 mol%. On the basis of the evidence presented in this study, strain YM155 represents a novel species of the genus Thalassotalea, for which we propose the name Thalassotalea profundi sp. nov. (type strain YM155=KACC 18563=CGMCC 1.15922).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1099/ijsem.0.002180 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design, synthesis, and evaluation of N,N-dialkyldioxonaphthoimidazoliums as antibacterial agents against methicillin-resistant Staphylococcus aureus.
Eur J Med Chem
June 2024
College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:
Increasing antibiotic resistance of bacterial pathogens poses a serious threat to human health worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) is among the most deleterious bacterial pathogens owing to its multidrug resistance, necessitating the development of new antibacterial agents against it. We previously identified a novel dioxonaphthoimidazolium agent, c5, with moderate antibacterial activity against MRSA from an anticancer clinical candidate, YM155.
View Article and Find Full Text PDFSepantronium Bromide (YM155), A Small Molecule Survivin Inhibitor, Promotes Apoptosis by Induction of Oxidative Stress, Worsens the Behavioral Deficits and Develops an Early Model of Toxic Demyelination: In Vivo and In-Silico Study.
Neurochem Res
November 2019
Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran.
Cuprizone (cup) model targets oligodendrocytes (OLGs) degeneration and is frequently used for the mechanistic understanding of de- and remyelination. Improperly, this classic model is time-consuming and the extent of brain lesions and behavioral deficits are changeable (both temporally and spatially) within a mouse strain. We aimed to offer an alternative, less time-consuming, and more reproducible cup model.
View Article and Find Full Text PDFThalassotaleaprofundi sp. nov. isolated from a deep-sea seamount.
Int J Syst Evol Microbiol
October 2017
Institute of Oceanology, Chinese Academy of Sciences, 266071, Qingdao, PR China.
The Gram-stain-negative, rod-shaped, strictly aerobic, motile bacterial strain, designated YM155, was isolated from a seamount near the Yap Trench in the tropical western Pacific. Phylogenetic analysis based on 16S rRNA gene sequence showed that strain YM155 was related to the genus Thalassotalea and had highest 16S rRNA gene sequence similarities with the type strains of Thalassotalea piscium T202 (97.2 %) and Thalassotalea agariperforans M-M1 (97.
View Article and Find Full Text PDFSystematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
BMC Cancer
July 2016
Institute for Molecular Medicine Finland (FIMM), Biomedicum 2U, Tukholmankatu 8, 00290, Helsinki, Finland.
Background: The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive cancers display de novo resistance to tamoxifen, and acquired resistance evolves in 40 % of patients who initially respond. Mechanisms underlying resistance development remain poorly understood and new therapeutic opportunities are urgently needed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!