AI Article Synopsis

  • The study investigates the link between asbestos exposure and esophageal cancer among workers in the ARDCo Program.
  • A 10-year follow-up of 14,515 male participants was conducted to assess the incidence and mortality rates of esophageal cancer after their asbestos exposure ended.
  • The results showed a significant connection, revealing that higher cumulative asbestos exposure increased both the risk of developing esophageal cancer and the likelihood of dying from it.

Article Abstract

Background: Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program).

Methods: A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos.

Results: We reported a significant dose-response relationship between CEI of exposure to asbestos and esophageal cancer, in both incidence (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.58), and mortality (HR 1.40, [95%CI 1.12-1.75]).

Conclusions: This large-scale study suggests the existence of a relationship between asbestos exposure and cancer of the esophagus.

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http://dx.doi.org/10.1002/ajim.22769DOI Listing

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