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Fostering healthy cognitive ageing in people living with HIV.
Lancet HIV
November 2024
MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health in people ageing with HIV that spans across public health, clinical spaces, and research spaces.
View Article and Find Full Text PDFCytokine release syndrome caused by immune checkpoint inhibitors: a case report and literature review.
Future Sci OA
December 2024
Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Immune checkpoint inhibitors (ICIs) have gained widespread application in the treatment of malignant tumors. Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infections and immunotherapy. We present a case of CRS occurring in a gastric cancer patient after receiving combination therapy of tislelizumab, anlotinib and combination of capecitabine and oxaliplatin.
View Article and Find Full Text PDFGiven the prevalence of hematological conditions, surgeries, and trauma incidents, hemostats-therapeutics designed to control and arrest bleeding-are an important tool in patient care. The prophylactic and therapeutic use of hemostats markedly enhances survival rates and improves the overall quality of life of patients suffering from these conditions. Since their inception in the 1960s, hemostats have witnessed remarkable progress in terms of the active ingredients utilized, therapeutic outcomes, demonstrated efficacy, and the storage stability.
View Article and Find Full Text PDFPhysical therapy in patients with Parkinson's disease treated with Deep Brain Stimulation: a Delphi panel study.
medRxiv
September 2024
"Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milan, Italy.
Article Synopsis
- Deep brain stimulation of the subthalamic nucleus (STN-DBS) offers motor benefits for Parkinson's disease patients, but its effectiveness on postural and gait issues remains uncertain.
- Physical therapy (PT) has shown effectiveness in improving mobility and stability in non-surgically treated Parkinson's patients, but its role after STN-DBS is less explored.
- A study involving 21 experts highlighted that while PT could enhance motor function and quality of life post-STN-DBS, there’s a preference for conventional therapies over massage or manual techniques.
Adaptive Deep Brain Stimulation in Parkinson's Disease: A Delphi Consensus Study.
medRxiv
August 2024
"Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milan, Italy.
Article Synopsis
- The evolution of Deep Brain Stimulation (DBS) is shifting from conventional methods to adaptive techniques (aDBS), which are expected to become standard practice in the next decade, similar to past advancements in cardiac pacing.
- Research involving 21 experts highlighted the challenges and potential of aDBS, showing consensus on its safety and effectiveness compared to conventional DBS, particularly for Parkinson's Disease patients with motor fluctuations and dyskinesias.
- Further studies are necessary to refine the algorithms used in aDBS, ensuring its widespread and effective use in clinical settings.
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