AI Article Synopsis
- - Researchers studied the role of Runx3 in human pancreatic cancer, particularly its effect on metastasis, building on findings from mouse models that showed high Runx3 levels increase cancer cell spread.
- - They analyzed 78 tumor samples from patients who had surgery for pancreatic cancer, finding varying levels of Runx3 expression, with 32 cases showing no expression and 46 showing different levels of positivity.
- - An optimal Runx3 cut-off value of 0.04 was identified, indicating that patients with this level or higher were significantly more likely to develop distant metastases, supporting Runx3's role in the spread of pancreatic cancer.
Article Abstract
Background/aim: In genetically engineered murine models of pancreatic ductal adenocarcinomas (PDAC), high levels of Runx3 increase the metastatic potential of cancer cells. In this study we evaluated the role of Runx3 in human pancreatic cancer.
Materials And Methods: Runx3 was retrospectively assessed by immunohistochemistry in seventy-eight tumor samples of patients who underwent surgical resection for PDCA and were followed at least for 24 months.
Results: Thirty-two cases resulted completely negative for Runx3; forty-six showed highly variable expression. We established an optimal cut-off value of Runx3 in predicting distant metastasis equal to 0.04. The odds ratio (ORs) for development of distant metastases at multivariate analysis for patients having Runx3 ≥0.04 was 4.26 (p=0.043) and 4.68 (p=0.032) after adjusting for residual tumor and treatment, respectively; OR for development of metastases in multiple sites was 4.28 (p=0.025) for Runx3 ≥0.04.
Conclusion: Our results support the ability of Runx3 to contribute to the dissemination of human PDAC thus confirming the observations from murine models.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656855 | PMC |
| http://dx.doi.org/10.21873/invivo.11136 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!