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Introduction: This report presents the latest findings from the National Health and Nutrition Examination Survey on the prevalence, awareness, treatment, and control of hypertension among adults in the United States during August 2021-August 2023.
Methods: Nationally weighted prevalence estimates of hypertension (systolic blood pressure of 130 mm Hg or above or diastolic blood pressure of 80 mm Hg or above, or self-report of current blood pressure medication use), self-reported awareness, self-reported treatment, and control (blood pressure less than 130/80 mm Hg) were obtained using National Health and Nutrition Examination Survey August 2021-August 2023 data. Variance estimates accounted for the complex survey design by using Taylor series linearization.
The Critical Role of HMGB1Cys106 in Regulating Sex-specific p53 Signaling in Pulmonary Arterial Hypertension.
Am J Respir Cell Mol Biol
March 2025
Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, United States;
High Mobility Group Box 1 (HMGB1) is a nuclear protein released from damaged cells and implicated in the pathogenesis of Pulmonary Arterial Hypertension (PAH) through activation of pro-inflammatory and pro-survival responses. However, the role of intracellular HMGB1 signaling, particularly its interactions with DNA and transcriptional regulation, remains underexplored. In this study, we investigated the role of intracellular HMGB1 and its critical residue Cys106 by engineering cell-penetrating peptide (αHMGB1Cys106) that mimics part of the HMGB1 dimeric interface surrounding Cys106.
View Article and Find Full Text PDFHypertension in Childhood Cancer Survivors: Causes, Screening, and Management.
Curr Hypertens Rep
March 2025
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
Purpose Of Review: Survivors of childhood cancer and hematopoietic cell transplant are at risk for developing chronic health conditions, including hypertension. Studies have identified hypertension as an influential risk factor for late kidney dysfunction and cardiovascular disease in childhood cancer survivors. The overall risk of hypertension depends on the specific cancer treatment, from chemotherapy to surgery to radiation.
View Article and Find Full Text PDFUnveiling the superiority: single catheter multisite epidural blood patch for the treatment of spontaneous intracranial hypotension.
Neurosurg Rev
March 2025
Department of Anaesthesia and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Spontaneous intracranial hypotension (SIH) is a rare clinical condition that may occur due to cerebrospinal fluid leakage. The purpose of this study was to compare the safety and efficacy of single catheter multisite epidural blood patch(CA-EBP) with standard procedures, including blinded and targeted epidural blood patch (EBP) for the treatment of SIH, and to investigate the effectiveness of dexamethasone as an adjuvant. Clinical data of 68 patients with postoperative SIH who underwent EBP between March 2022 and May 2024.
View Article and Find Full Text PDFOvernight stiffness index from finger photoplethysmography in relation to markers of cardiovascular risk and vascular ageing.
Heart Vessels
March 2025
Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Wearable technology, such as photoplethysmography (PPG), enables easily accessible individual health data with the potential for improved risk assessment. We hypothesized that the overnight stiffness index (OSI), derived from nocturnal finger PPG, could be used to assess cardiovascular risk and vascular ageing. Subjects with confirmed or suspected hypertension (n = 79, 56 males) underwent simultaneous ambulatory blood pressure monitoring (ABPM) and overnight sleep polygraphy with a continuous PPG registration.
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