AI Article Synopsis
- - Adrenocortical carcinoma is a rare type of cancer with a poor outlook, and while researchers have made progress in understanding its genetic causes, there's still much to learn about how it spreads.
- - One major challenge in developing new treatments for this cancer is the lack of effective animal models that can study metastatic disease.
- - This study successfully created a mouse model through a specific injection method, allowing researchers to track cancer spread using bioluminescence, which will enhance preclinical testing for advanced treatments.
Article Abstract
Adrenocortical carcinoma is a rare neoplasm with a poor prognosis. Very important advances have been made in the identification of the genetic determinants of adrenocortical carcinoma pathogenesis but our understanding is still limited about the mechanisms that determine cancer spread and metastasis. One major problem hindering preclinical experimentation for new therapies for adrenocortical carcinoma is represented by the lack of suitable animal models for metastatic disease. With the aim to overcome these limitations, in this study we tested several protocols in order to establish a mouse xenograft model of metastatic adrenocortical carcinoma. The most efficient method, based upon intrasplenic injection followed by splenectomy, produced metastases with high efficiency, whose development could be followed over time by bioluminescence measurements. We expect that the availability of this model will greatly improve the possibilities for preclinical testing of new treatments for advanced-stage disease.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584229 | PMC |
| http://dx.doi.org/10.18632/oncotarget.16909 | DOI Listing |
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