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Macrophages promote the progression of premalignant mammary lesions to invasive cancer. | LitMetric

AI Article Synopsis

  • Breast cancer development involves complex interactions between tumor cells and their surrounding environment, particularly immune cells like macrophages.
  • This study investigates the role of macrophages in early-stage breast lesions, demonstrating that they are recruited to high-risk areas and adopt a phenotype that promotes tumor growth.
  • Targeting these tumor-promoting macrophages could be a promising strategy for preventing breast cancer progression and metastasis.

Article Abstract

Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less is known about the role of macrophages in early stage lesions. In this study, we utilized a transplantable p53-null model of early progression to characterize the immune cell components of early stage lesions. We show that macrophages are recruited to ductal hyperplasias with a high tumor-forming potential where they are differentiated and polarized toward a tumor-promoting phenotype. These macrophages are a unique subset of macrophages, characterized by pro-inflammatory, anti-inflammatory and immunosuppressive factors. Macrophage ablation studies showed that macrophages are required for both early stage progression and primary tumor formation. These studies suggest that therapeutic targeting of tumor-promoting macrophages may not only be an effective strategy to block tumor progression and metastasis, but may also have critical implications for breast cancer prevention.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584199PMC
http://dx.doi.org/10.18632/oncotarget.14913DOI Listing

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