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| http://dx.doi.org/10.7554/eLife.31512 | DOI Listing |
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Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease.
Eur J Endocrinol
December 2020
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Objective: Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)). Both transmembrane proteins have been described as autoantigens in thyroid disease, yet the reports on autoantibody (aAb) prevalence and diagnostic usefulness are conflicting. Reasons for the inconclusive findings may be small study groups and principle differences in the technologies used.
View Article and Find Full Text PDFRe-visiting the relationship between neighbourhood environment and BMI: an instrumental variables approach to correcting for residential selection bias.
Int J Behav Nutr Phys Act
February 2013
Department of Family and Consumer Studies, University of Utah, 225 South 1400 East, Room 220, 84112, Salt Lake City, UT 84112, USA.
Background: A burgeoning literature links attributes of neighbourhoods' built environments to residents' physical activity, food and transportation choices, weight, and/or obesity risk. In cross-sectional studies, non-random residential selection impedes researchers' ability to conclude that neighbourhood environments cause these outcomes.
Methods: Cross-sectional data for the current study are based on 14,689 non-Hispanic white women living in Salt Lake County, Utah, USA.
Regime change: re-visiting the 1961 Single Convention on Narcotic Drugs.
Int J Drug Policy
January 2012
Department of Political and Cultural Studies, College of Arts and Humanities, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
Background: March 2011 marked the 50th anniversary of the Single Convention on Narcotic Drugs. This legal instrument, the bedrock of the current United Nations based global drug control regime, is often viewed as merely a consolidating treaty bringing together the multilateral drug control agreements that preceded it; an erroneous position that does little to provide historical context for contemporary discussions surrounding revision of the international treaty system.
Method: This article applies both historical and international relations perspectives to revisit the development of the Convention.
Priority setting for health technology assessments: a systematic review of current practical approaches.
Int J Technol Assess Health Care
August 2007
Canadian Agency for Drugs and Technologies in Health, Ottawa, Ontario, Canada. [corrected]
Objectives: This study sought to identify and compare various practical and current approaches of health technology assessment (HTA) priority setting.
Methods: A literature search was performed across PubMed, MEDLINE, EMBASE, BIOSIS, and Cochrane. Given an earlier review conducted by European agencies (EUR-ASSESS project), the search was limited to literature indexed from 1996 onward.
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