Tumor Necrosis Factor Alpha Inhibitor-Induced Acute Pancreatitis.

ACG Case Rep J

Division of Gastroenterology, Fox Chase Cancer Center, Philadelphia, PA.

Published: August 2017

Treatment of acute pancreatitis remains a challenge, with therapy focused on supportive care and treating the inciting etiology. Tumor necrosis factor-alpha (TNFα) inhibitors have shown promising results treating acute pancreatitis in animal models, but they have not been evaluated in human trials yet. A 25-year-old woman presented with ulcerative colitis. She was unresponsive to immunomodulators and developed acute pancreatitis shortly after initiation of a TNFα inhibitor. Her symptoms subsided after discontinuation of the medication, but reemerged when a different TNFα inhibitor was introduced to control her ulcerative colitis. Other potential etiologies were investigated and clinically excluded by laboratory and imaging studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577046PMC
http://dx.doi.org/10.14309/crj.2017.103DOI Listing

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