Background: Cardiovascular (CV) and thermal responses to metabolically demanding multi-day military operations in extreme cold-weather environments are not well described. Characterization of these operations will provide greater insights into possible performance capabilities and cold injury risk.
Methods: Soldiers from two cold-weather field training exercises (FTX) were studied during 3-day (study 1, = 18, age: 20 ± 1 year, height: 182 ± 7 cm, mass: 82 ± 9 kg) and 4-day (study 2, = 10, age: 20 ± 1 year, height: 182 ± 6 cm, mass: 80.7 ± 8.3 kg) ski marches in the Arctic. Ambient temperature ranged from -18 to -4 °C during both studies. Total daily energy expenditure (TDEE, from doubly labeled water), heart rate (HR), deep body (), and torso () skin temperature (obtained in studies 1 and 2) as well as finger (), toe (), wrist, and calf temperatures (study 2) were measured.
Results: TDEE was 6821 ± 578 kcal day and 6394 ± 544 for study 1 and study 2, respectively. Mean HR ranged from 120 to 140 bpm and mean ranged between 37.5 and 38.0 °C during skiing in both studies. At rest, mean ranged from 36.0 to 36.5 °C, (lowest value recorded was 35.5 °C). Mean ranged from 32 to 35 °C during exercise and dropped to 15 °C during rest, with some values as low as 6-10 °C. T was above 30 °C during skiing but dropped to 15-20 °C during rest.
Conclusions: Daily energy expenditures were among the highest observed for a military training exercise, with moderate exercise intensity levels (~65% age-predicted maximal HR) observed. The short-term cold-weather training did not elicit high CV and strain. and were also well maintained while skiing, but decreased to values associated with thermal discomfort at rest.
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http://dx.doi.org/10.1186/s13728-017-0056-6 | DOI Listing |
Nat Struct Mol Biol
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Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
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January 2025
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable of performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in a murine brain. We have termed it the All-in-One FUS system for murine brain studies, which is the first FUS system of its kind. The 1.
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College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, China.
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