We propose an analytical technique to study large fluctuations and switching from internal noise in complex networks. Using order-disorder kinetics as a generic example, we construct and analyze the most probable, or optimal path of fluctuations from one ordered state to another in real and synthetic networks. The method allows us to compute the distribution of large fluctuations and the time scale associated with switching between ordered states for networks consistent with mean-field assumptions. In general, we quantify how network heterogeneity influences the scaling patterns and probabilities of fluctuations. For instance, we find that the probability of a large fluctuation near an order-disorder transition decreases exponentially with the participation ratio of a network's principle eigenvector - measuring how many nodes effectively contribute to an ordered state. Finally, the proposed theory is used to answer how and where a network should be targeted in order to optimize the time needed to observe a switch.
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http://dx.doi.org/10.1038/s41598-017-08828-8 | DOI Listing |
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January 2025
Department of Pediatrics, Section of Allergy and Immunology, University of Colorado School of Medicine, Aurora, Colorado, USA.
A reduced proportion of peripheral class-switched memory B cells (CSM-B cells) is presumed to indicate ineffective germinal activity. The extent that this finding corresponds to a plausible germinal center failure pathophysiology in patients not diagnosed with CVID or hyper IgM syndrome is not known. We asked if patients with low CSM-B cells are more likely to demonstrate failure to produce serum IgA and IgG than counterparts with nonreduced class-switched memory B cell levels, regardless of diagnosis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Background: Highly specific ATN plasma biomarker assays for neurodegenerative diseases have been developed, but their associations with cognition vary in different populations. Kidney disease, common in diabetes, may decrease the predictive precision of those biomarkers. The aim of this study was to characterize for the first time the relationships between plasma ATN biomarkers and cognitive function in adults with T1D.
View Article and Find Full Text PDFBackground: Preventative interventions for cognitive decline are crucial as the number of individuals with Dementia is projected to reach 78 million by 2030. Cognitive Training can be a promising solution for the maintenance and improvement of neurocognitive functioning and has the potential to delay the onset of AD. This study utilizes a home-based gamified cognitive training, the Bird Watch Game Unity (BWGU), where participants engage aspects of cognitive control to focus on predictable and unpredictable probe-cue sequences of novel visual stimuli - pictures of birds.
View Article and Find Full Text PDFeNeuro
January 2025
Cognitive Psychology Unit, Faculty of Social Sciences, Leiden University, Wassenaarseweg 52 2333 AK, Leiden, Netherlands.
The brain attends to environmental rhythms by aligning the phase of internal oscillations. However, the factors underlying fluctuations in the strength of this phase entrainment remain largely unknown. In the present study we examined whether the strength of low-frequency EEG phase entrainment to rhythmic stimulus sequences varied with pupil size and posterior alpha-band power, thought to reflect arousal level and excitability of posterior cortical brain areas, respectively.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Hangzhou Institute of Technology, Xidian University, Hangzhou 311200, China.
A highly sensitive sulfur dioxide (SO) photoacoustic gas sensor was developed for the sulfur hexafluoride (SF) decomposition detection in electric power systems by using a novel 266 nm low-cost high-power solid-state pulse laser and a high -factor differential photoacoustic cell. The ultraviolet (UV) pulse laser is based on a passive -switching technology with a high output power of 28 mW. The photoacoustic signal was normalized to the laser power to solve the fluctuation of the photoacoustic signal due to the power instability of the UV laser.
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