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Environmental stress is the major cause of transcriptomic and proteomic changes in GM and non-GM plants. | LitMetric

Environmental stress is the major cause of transcriptomic and proteomic changes in GM and non-GM plants.

Sci Rep

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Av. da República, 2780-157, Oeiras, Portugal.

Published: September 2017

AI Article Synopsis

  • The approval process for genetically modified (GM) crops involves extensive research to ensure their safety for humans and the environment, with a recent study highlighting that culture stress significantly influences differences between GM and non-GM plants.
  • The study tracked the changes in three rice lines over eight generations after genetic modification, investigating the impacts of transgenesis versus environmental stress, particularly salinity.
  • Findings indicate that genetic modifications mostly cause short-term physiological changes that decrease over generations, while environmental stress leads to greater alterations in plant proteomics and transcriptomics, sparking questions about the efficacy of current GM food crop risk assessment methods.

Article Abstract

The approval of genetically modified (GM) crops is preceded by years of intensive research to demonstrate safety to humans and environment. We recently showed that in vitro culture stress is the major factor influencing proteomic differences of GM vs. non-GM plants. This made us question the number of generations needed to erase such "memory". We also wondered about the relevance of alterations promoted by transgenesis as compared to environment-induced ones. Here we followed three rice lines (1-control, 1-transgenic and 1-negative segregant) throughout eight generations after transgenesis combining proteomics and transcriptomics, and further analyzed their response to salinity stress on the F6 generation. Our results show that: (a) differences promoted during genetic modification are mainly short-term physiological changes, attenuating throughout generations, and (b) environmental stress may cause far more proteomic/transcriptomic alterations than transgenesis. Based on our data, we question what is really relevant in risk assessment design for GM food crops.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587699PMC
http://dx.doi.org/10.1038/s41598-017-09646-8DOI Listing

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