Objective: To cross-sectionally study subjective memory complaints (SMC) in autosomal dominant Alzheimer disease (ADAD).
Methods: We examined self-reported and study partner-based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD. Twenty-six carried the E280A mutation, averaging 7 years of age younger than the kindred's expected clinical onset. Twenty-six were age-matched noncarriers. Participants also underwent structural MRI and cognitive testing.
Results: Self-reported SMC were greater in carriers than noncarriers ( = 0.02). Study partner-based SMC did not differ between groups ( = 0.21), but in carriers increased with age ( = 0.66, < 0.001) and decreased with hippocampal volume ( = -0.35, = 0.08).
Conclusions: Cognitively unimpaired carriers have elevated SMC. Self-reported SMC may be a relatively early indicator of preclinical AD, while partner- reported SMC increases later in preclinical AD, closer to clinical onset.
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| http://dx.doi.org/10.1212/WNL.0000000000004533 | DOI Listing |
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