Background: To investigate the early and late antiadhesive effect and any changes of fibrin matrix regulation enzymes on rat peritoneum, after local administration of bevacizumab.
Methods: Rats were subjected to cecal abrasion. Bevacizumab (5 mg/kg) against placebo was given intraperitoneally. On the 2nd, 14th, and 28th postoperative days adhesions were scored, and tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 (MMP-9), degree of fibrosis, and angiogenesis were measured in abrased cecum and in intact parietal peritoneum.
Results: Bevacizumab significantly reduced adhesions up to 15% on the 2nd, 52.5% on the 14th, and 55% on the 28th postoperative day, and significantly increased tPA concentrations in peritoneum. PAI-1 was decreased, and a significantly higher tPA/PAI-1 ratio along with an increase of MMP-9 was measured at all time points. Fibrosis and angiogenesis were significantly lower on the 14th and 28th postoperative days.
Conclusions: Local bevacizumab administration has a strong early and late antiadhesive action on rat peritoneum, mediated by changes in the tPA/PAI-1 and MMP balance in favor of fibrinolysis up to 28 days after operations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1553350617729510 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Peritoneal histopathological changes and cultures after autogenous fecal peritonitis induced in elderly rat model: response to intravenous use of meropenem and intra-abdominal inoculation of 10% aqueous extract of Schinus Terebinthifolius Raddi (Anacardiaceae).
Acta Cir Bras
January 2025
Universidade Federal de Pernambuco - Hospital das Clínicas - Recife (PB) - Brazil.
Purpose: To evaluate the peritoneal histopathological changes and culture after the use of intravenous meropenem and intra-abdominal inoculation of 10% aqueous extract of anacardiaceae, in elderly rat model after autogenous fecal peritonitis induced.
Methods: Thirty 18-month-old Wistar rats received induction of autogenous fecal peritonitis and then were stratified into two groups: study I, treated with meropenem (40 mg/kg); and study II, treated with meropenem (40 mg/kg) and intraperitoneal 10% aqueous extract of anacardiaceae. Animals were monitored for 15 days until euthanasia.
Severe degranulation of mesenteric mast cells in an experimental rat mammary tumor model.
Turk J Med Sci
December 2024
Department of Pathology, Faculty of Veterinary Medicine, Bursa Uludağ University, Bursa, Turkiye.
Background/aim: Breast cancers are one of the most common cancers in women and are responsible for many deaths worldwide. Mast cells are inflammatory cells. Their role in cancers is controversial, and there is limited data on systemic mast cell activation in cancer cases.
View Article and Find Full Text PDFBacterial Cellulose Membrane Experimentally Implanted in the Peritoneum of Wistar Rats-Inflammatory Immunoreactivity and Oxidative Stress.
Curr Issues Mol Biol
October 2024
Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu 18610-307, SP, Brazil.
Bacterial cellulose (BC) has been used for various applications; however, studies investigating the immunohistochemical characteristics of the inflammatory and scarring component in BC implanted in the peritoneum in vivo have not yet been fully described. This study aimed to evaluate the systemic and organic safety of BC through oxidative stress, blood, and serum biochemical markers, as well as the late inflammatory response in rats, using histopathology and immunohistochemistry. Forty-three rats (26 males; 17 females) received BC in the peritoneal cavity (implanted group-IG), while twenty-seven rats (12 males; 15 females) served as the control (sham group-SG).
View Article and Find Full Text PDFGenistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway.
Sci Rep
October 2024
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Institute of Endocrinology, Chu Hsien-I Memorial Hospital, Tianjin Medical University, Tianjin, 300134, China.
Article Synopsis
- Peritoneal fibrosis in dialysis is tied to hypoxia-inducible factor 1-alpha (HIF-1α) and O-linked-N-acetylglucosaminylation (O-GlcNAcylation).
- Genistein, known for its anti-fibrotic and HIF-1α inhibiting properties, may help combat peritoneal mesothelial-mesenchymal transition (MMT) and fibrosis in patients undergoing peritoneal dialysis.
- In a study with human peritoneal mesothelial cells and chronic kidney disease rats, Genistein demonstrated effectiveness in reducing fibrosis and improving peritoneal function by targeting HIF-1α through the mTOR/OGT pathway
[Contractive function of mesenteric lymph nodes in obese rats].
Vopr Pitan
October 2024
Pavlov Institute of Physiology, Russian Academy of Sciences, 199034, St. Petersburg, Russian Federation.
Over the past 50 years, the prevalence of obesity around the world has increased several times and has become a pandemic. The effect of obesity on the lymphatic system, which plays a key role in the regulation of fluid homeostasis, immune cell migration, antigen presentation, and resolution of inflammatory responses, is poorly understood, and there is no data on the contractile activity of the lymph nodes in obesity. of the research was to investigate the parameters and mechanisms of dysfunction of the contractile function of the mesenteric lymph nodes of rats in obesity caused by the feeding with the high-fat diet (HFD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!