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Therapeutic novelties in acute heart failure and practical perspectives.
Anaesth Crit Care Pain Med
January 2025
City Cardiological Center, Almaty, Kazakhstan.
Acute Heart Failure (AHF) is a leading cause of death and represents the most frequent cause of unplanned hospital admission in patients older than 65 years. Since the past decade, several randomized clinical trials have highlighted the importance and pivotal role of certain therapeutics, including decongestion by the combination of loop diuretics, the need for rapid goal-directed medical therapies implementation before discharge, risk stratification, and early follow-up after discharge therapies. Cardiogenic shock, defined as sustained hypotension with tissue hypoperfusion due to low cardiac output and congestion, is the most severe form of AHF and mainly occurs after acute myocardial infarction, which can progress to multiple organ failure.
View Article and Find Full Text PDFGastric Ultrasound in the Management of Emergency Department Patients with Upper Gastrointestinal Bleeding: A Case Series and Sonographic Technique.
J Emerg Med
January 2025
Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.
Background: Gastrointestinal bleeding (GIB) is a common condition in the emergency department (ED) with high incidence and mortality.
Objectives: Very early risk stratification of GIB patients can sometimes be a challenge. The decision to intubate these patients is multifactorial and requires careful consideration.
Transcriptional determinants of goal-directed learning and representational drift in the parahippocampal cortex.
Cell Rep
January 2025
Department of Biology, Boston University, Boston, MA 02215, USA; Center for Neurophotonics, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Center for Systems Neuroscience, Boston University, Boston MA 02215, USA. Electronic address:
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- Task learning involves forming and storing associations between stimuli and outcomes in memory, but individual neuron representations can change over time.
- Researchers used two-photon calcium imaging and spatial transcriptomics to study neuron activity and gene expression in the perirhinal cortex during task training.
- Deleting brain-derived neurotrophic factor disrupted gene expression and task learning, while prolonged training reduced representational drift and strengthened existing memory representations, highlighting key cellular mechanisms in memory stability.
Creativity and Mental Illness: A Case Study of a Patient with Progressive Bulbar Palsy.
Brain Sci
November 2024
Clinical Neuroanatomy, Department of Neurology, University Hospital Ulm, 89081 Ulm, Germany.
Creativity and the production of artwork can have an impact on the course and treatment of comorbid severe mental illness and neurodegeneration. We report on a 70-year-old male patient with highly original artistic behavior, who suffered from lifelong recurrent major depression and subsequently developed symptoms of progressive bulbar palsy (PBP). In the context of a systematic literature review, we detail the patient's personal and artistic biographies and portray artwork from his artistic portfolio together with his disease history, clinical examination, psychopathological and neuropsychological evaluations, blood and cerebrospinal fluid analyses, neuroimaging, neurophysiological testing, and psychotherapeutic treatment.
View Article and Find Full Text PDFAtypical development of sequential manual motor planning and visuomotor integration in children with autism at early school-age: A longitudinal kinematic study.
Autism
January 2025
Department of Psychology, Umeå University, Sweden.
Many children with autism struggle with movement difficulties, yet the causes of these difficulties remain unclear. One possible explanation is atypical motor planning and integration of visual and motoric information. Before performing a goal-directed movement, the brain creates a prediction of the movement based on visual and sensory information and previous experience, forming a "blueprint" of the motor steps needed to achieve the goal.
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