AI Article Synopsis
- Researchers developed ampelopsin-loaded nanomicelles using pluronic F127 and TPGS1000 to enhance the drug's solubility and effectiveness against cancer.
- The optimal nanomicelles were approximately 22.6 nm in size, with 80.42% encapsulation efficiency and a significant 16-fold increase in ampelopsin solubility.
- In tests, the nanomicelles released over 90% of the drug in 8 hours and demonstrated greater cytotoxicity against MCF-7 cancer cells, suggesting they could serve as an effective drug delivery system.
Article Abstract
To improve the solubility and antitumor activity of ampelopsin, ampelopsin-loaded nanomicelles from the mixture of pluronic F127 and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS1000) were prepared by film-thin hydration method, in order to optimize the process conditions and physicochemical properties. The antitumor activities against MCF-7 cells between ampelopsin and nanomicelles were compared by MTT method, respectively. The results showed that the optimal nanomicelles were round with the nanometric size of (22.6±0.5) nm, encapsulation efficiency rate of (80.42±1.13)%, and drug-loading rate of (4.41±0.26)%. The solubility of ampelopsin in mixed nanomicelles significantly increased by 16 times. In different release media, the mixed nanomicelles could release more than 90% of drug in 8 h, and showed stronger cytotoxicity and inhibition against MCF-7 cells (P<0.01). The mixed nanomicelles can be used as new drug delivery system of ampelopsin.
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| http://dx.doi.org/10.4268/cjcmm20160613 | DOI Listing |
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