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Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity.
Clin Cosmet Investig Dermatol
January 2025
Lugansk state medical University, Department of Pathology, Rivne, Ukraine.
Introduction: Marie-Unna hereditary hypotrichosis (MUHH) is an autosomal dominant disorder characterized by a specific pattern of hair loss. Initially described in 1925 by Marie-Unna in a German family spanning over seven generations, MUHH represents a previously unidentified form of congenital hypotrichosis. It typically presents as sparse hair at birth with a coarse texture, followed by regrowth during childhood then, finally, gradual hair loss at puberty, resembling pattern of androgenetic alopecia.
View Article and Find Full Text PDFAutosomal recessive hereditary hypotrichosis simplex: A case report.
JAAD Case Rep
February 2025
Department of Dermatology, King Fahad General Hospital, Jeddah, Saudi Arabia.
Hereditary hypotrichosis simplex with SNRPE gene mutation.
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, School of Medicine, Pusan National University, Seo-Gu, Busan, Republic of Korea, Korea.
MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia.
Eur J Pharmacol
December 2024
Department of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310009, China; Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, 310009, China. Electronic address:
Increased sensitivity to androgens and androgen receptors is the underlying cause of androgenetic alopecia (AGA), a hereditary disease. Our study investigated the preventive effects of MitoQ on dihydrotestosterone (DHT)-induced mitochondrial dysfunction and subsequent hair loss from three perspectives: in vivo, in vitro, and network pharmacology. A mouse model of AGA was used to assess the effectiveness of MitoQ intervention.
View Article and Find Full Text PDFInvestigating the role of keratin proteins and microbial associations in hereditary and pathogenic alopecia.
Arch Dermatol Res
October 2024
Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, Pakhtunkhwa, Pakistan.
The purpose of this research was to identify the role of keratin proteins in causing inherited as well as pathogenic alopecia, pinpoint deleterious SNPs, and predict structural changes affecting protein-protein interactions in hair disorders. To elucidate the role of keratin proteins and genetic mutations in alopecia by analyzing protein structures through bioinformatics and identifying a mutation in the LPAR6 gene. It sought to identify the microorganisms linked to alopecia and conducted a comprehensive bioinformatics analysis of proteins with unknown experimental structures and molecular simulation analysis.
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