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Serum IL-6 and IL-8 Correlate with Prognostic Factors in Ovarian Cancer. | LitMetric

AI Article Synopsis

  • * A total of 26 patients with confirmed malignant ovarian tumors were evaluated, with blood samples analyzed for cytokine levels and tumor markers before surgery, using the ELISA method.
  • * Results indicated that higher levels of IL-6 were linked to poorer overall survival (less than 60 months), while elevated IL-8 levels correlated with worse prognostic factors, suggesting that these cytokines could be important in understanding ovarian cancer prognosis and treatment strategies.

Article Abstract

The aim of the study was to correlate serum levels of IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α with clinical, laboratory, and pathological prognostic factors in patients with primary ovarian malignancy. Patients treated at the Pelvic Mass Ambulatory of the Discipline of Gynecology and Obstetrics/Oncology Research Institute (IPON) of the UFTM with confirmed diagnosis of malignant ovarian neoplasia (n = 26) were evaluated. Serum collection was performed preoperatively for the determination of tumor markers. The cytokines IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α were assayed by enzyme-linked immunosorbent assay (ELISA). The prognostic factors were compared using the Mann-Whitney test, with significance level lower than 0.05. When evaluating IL6, it was observed that higher serum levels were associated with overall survival less than 60 months (p = 0.0382). In the evaluation of IL8, higher serum levels were associated with neutrophil-to-lymphocyte ratio (NLR) ≥ 4 and platelet-to-lymphocyte ratio (PLR) ≥ 200 (p = 0.0198 and p = 0.0072, respectively), altered values of serum CA125 (p = 0.0457), and stage IIIC (p = 0.0486). Therefore, increased levels of IL-6 and IL-8 are associated with factors of worse prognosis in ovarian cancer. Additional studies with a larger sample of patients are needed to confirm the role of cytokines as prognostic factors, in the definition of treatment, and in the development of future target therapies.

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Source
http://dx.doi.org/10.1080/08820139.2017.1360342DOI Listing

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