Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia.

Mycoses

Institute of Hematology "Lorenzo e Ariosto Seràgnoli", Department of Specialistic Diagnostic and Experimental Medicine (DIMES), Sant'Orsola-Malpighi Hospital Teaching Hospital, University of Bologna, Bologna, Italy.

Published: January 2018

AI Article Synopsis

Article Abstract

Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy. We also review published literature describing the management of endogenous Fusarium endophthalmitis in immunocompromised hosts.

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12697DOI Listing

Publication Analysis

Top Keywords

endogenous fusarium
8
fusarium solani
8
patient acute
8
successful treatment
4
treatment bilateral
4
bilateral endogenous
4
fusarium
4
solani endophthalmitis
4
endophthalmitis patient
4
acute lymphocytic
4

Similar Publications

In order to scientifically search for new sources of secondary metabolites with valuable qualities for phytopharmacognosy, tasks requiring a step-by-step solution were set. The primary task is the development of technologies for obtaining in vitro highly productive biomass of cells of relict gymnosperms of the genus , capable of accumulating various classes of secondary metabolites. The study of the accumulation and localization of secondary metabolites allowed us to evaluate the biological activity and cytotoxicity of in vitro cultures.

View Article and Find Full Text PDF

Fusarium oxysporum disrupts redox homeostasis in Vigna mungo, likely by interfering with salicylic acid signaling, which can be ameliorated by boosting PAL and its related pathways via salicylic acid pretreatment. Fusarium oxysporum, a widespread soil-borne fungus, significantly threatens global crops. This study centers on elucidating the infection strategies employed by F.

View Article and Find Full Text PDF

We describe a unique case of sclerouveitis that progressed to endogenous endophthalmitis in a 69-year-old male with chronic lymphocytic leukemia (CLL). We highlight the risk of treating sclerouveitis with oral corticosteroids, which can exacerbate an infection and contribute to disease progression. A 69-year-old male with CLL on zanubrutinib, a second-generation Bruton's tyrosine kinase inhibitor, was admitted to the hospital for osteomyelitis of the left foot.

View Article and Find Full Text PDF

Pathobiology of Fungal Endophthalmitis: A Major Review.

ACS Infect Dis

September 2024

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034, India.

Fungal endophthalmitis is a chronic inflammatory condition of the eye's posterior segment that can lead to irreversible vision loss. While relatively rare in western countries, its incidence is notably higher in Asia, particularly India. The condition's prevalence is exacerbated by factors such as intravenous drug use, antibiotics, and ocular surgeries.

View Article and Find Full Text PDF

Continuous cropping of peanuts presents significant challenges to sustainable production due to soil-borne diseases like root rot caused by Fusarium species. In this study, field inoculation experiments treatments and in vitro agar plate confrontation tests were conducted, including non-inoculated controls (CK), inoculation with Pseudomonas fluorescens (PF), Fusarium oxysporum (FO), and co-inoculation with both (PF + FO). The aim was to explore the antifungal mechanisms of Pseudomonas fluorescens in mitigating root rot and enhancing peanut yield.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!