Purpose: Reaction time has been proposed as a training monitoring tool, but to date, results are equivocal. Therefore, it was investigated whether reaction time can be used as a monitoring tool to establish overreaching.
Methods: The study included 30 subjects (11 females and 19 males, age: 40.8 [10.8] years, VO: 51.8 [6.3] mL/kg/min) who participated in an 8-day cycling event. The external exercise load increased approximately 900% compared with the preparation period. Performance was measured before and after the event using a maximal incremental cycling test. Subjects with decreased performance after the event were classified as functionally overreached (FOR) and others as acutely fatigued (AF). A choice reaction time test was performed 2 weeks before (pre), 1 week after (post), and 5 weeks after (follow-up), as well as at the start and end of the event.
Results: A total of 14 subjects were classified as AF and 14 as FOR (2 subjects were excluded). During the event, reaction time at the end was 68 ms (95% confidence interval, 46-89) faster than at the start. Reaction time post event was 41 ms (95% confidence interval, 12-71) faster than pre event and follow-up was 55 ms faster (95% confidence interval, 26-83). The time by class interaction was not significant during (P = .26) and after (P = .43) the event. Correlations between physical performance and reaction time were not significant (all Ps > .30).
Conclusions: No differences in choice reaction time between AF and FOR subjects were observed. It is suggested that choice reaction time is not valid for early detection of overreaching in the field.
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http://dx.doi.org/10.1123/ijspp.2017-0218 | DOI Listing |
PLoS One
January 2025
Graduate School of Humanities and Social Sciences, Kyoto University of Advanced Science, Kyoto, Japan.
The joint Simon effect refers to inhibitory responses to spatially competing stimuli during a complementary task. This effect has been considered to be influenced by the social factors of a partner: sharing stimulus-action representation. According to this account, virtual interactions through their avatars would produce the joint Simon effect even when the partner did not physically exist in the same space because the avatars are intentional agents.
View Article and Find Full Text PDFJ Cancer Res Ther
December 2024
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, People's Republic of China.
Phys Chem Chem Phys
January 2025
The Fritz Haber Center for Molecular Dynamics, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Peroxy radicals are key intermediates in many atmospheric processes. Reactions between such radicals are of particular interest as they can lead to accretion products capable of participating in new particle formation (NPF). These reactions proceed through a tetroxide intermediate, which then decomposes to a complex of two alkoxy radicals and O, with spin conservation dictating that the complex must be formed in the triplet state.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, United States.
Purpose: Sulfur mustard gas (SM) exposure to eyes causes multiple corneal injuries including stromal cell loss in vivo. However, mechanisms mediating stromal cell loss/death remains elusive. This study sought to test the novel hypothesis that SM-induced toxicity to human corneal stromal fibroblasts involves ferroptosis mechanism via p38 MAPK signaling.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Purpose: Dry eye disease (DED) is a common ocular surface inflammatory disease with a complex pathogenesis. Herein, the role and effect of gasdermin E (GSDME) in DED pathogenesis were explored.
Methods: In vitro, flow cytometry, Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) release assays were used to determine the effects of hyperosmotic stress on pyroptosis, apoptosis, and cell viability in human corneal epithelial cells (HCECs).
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