Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, the availability and use of substandard and spurious quality of oral ciprofloxacin formulations in the developing countries has been thought to have contributed toward increased risk of treatment failure and bacterial resistance. Therefore, quality control and bioequivalence studies of the commercially available oral ciprofloxacin formulations should be monitored. Appropriate actions should be taken against offending manufacturers in order to prevent the sale of substandard and spurious quality of ciprofloxacin formulations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566961 | PMC |
| http://dx.doi.org/10.3389/fphar.2017.00546 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multifunctional electrospun nanofiber films of polyacrylonitrile and polyvinyl alcohol incorporating rhamnose and therapeutic agents for enhanced healing of infected burn wounds.
J Biomater Sci Polym Ed
January 2025
Department of Microbiology, University of Central Punjab, Lahore, Pakistan.
Infected burn wounds present significant clinical challenges due to delayed healing and risk of infection, necessitating advanced treatments that offer both antimicrobial and regenerative properties. This study aimed to develop and evaluate multifunctional electrospun nanofiber films incorporating rhamnose (as an angiogenic agent) and therapeutic agents, namely fluticasone, mupirocin, ciprofloxacin, and silver sulfadiazine, for the enhanced healing of infected burn wounds. Nanofibers containing rhamnose, polyacrylonitrile, polyvinyl alcohol and therapeutic agents were fabricated electrospinning.
View Article and Find Full Text PDFExploring the Potential of Nitrofurantoin for Infection Control in Regenerative Endodontics: In Vitro Study.
J Endod
December 2024
Postgraduate Program in Dentistry of Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil; Geriatric Dentistry Department, Faculty of Dentistry of Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil; Laboratory of Experimental Culture Cell (LECCel), Faculty of Dentistry of Fluminense, Federal University (UFF), Niteroi, Rio de Janeiro, Brazil; Endodontics Department, Faculty of Dentistry of Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil. Electronic address:
Introduction: This study assessed a new antimicrobial paste formulation containing nitrofurantoin for regenerative endodontics against multispecies biofilms.
Methods: Four groups of 11 single-root teeth each were tested: Negative control group (brain-heart infusion broth + micro-organisms); Hoshino 1 conventional tri-antibiotic paste group (1:1:1 ratio); Hoshino 5 group (5:5:5 ratio); Experimental group with nitrofurantoin, ciprofloxacin, and metronidazole. Minimum inhibitory concentrations of each antimicrobial were determined.
Novel benzothiazole derivatives target the Gac/Rsm two-component system as antibacterial synergists against infections.
Acta Pharm Sin B
November 2024
State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou 510632, China.
The management of antibiotic-resistant, bacterial biofilm infections in skin wounds poses an increasingly challenging clinical scenario. infection is difficult to eradicate because of biofilm formation and antibiotic resistance. In this study, we identified a new benzothiazole derivative compound, (IC = 43.
View Article and Find Full Text PDFElectrostatic adsorptive loading of ciprofloxacin and metronidazole on chitosan nanoparticles to prolong the drug delivery process with preserved antibacterial activities: formulation and characterization.
Nanoscale Adv
January 2025
Department of Chemistry, Faculty of Science, University of Dhaka Dhaka-1000 Bangladesh
This study presents the formulation and evaluation of chitosan-based homogeneous nanoparticles of ciprofloxacin (CP) and metronidazole (MTZ) with improved loading efficiency to enhance the controlled release of drug within the human body as well as for the enhancement of the antibacterial activity. The drug-loaded chitosan nanoparticles (CSNPs) were prepared using deacetylated chitosan extracted from shrimp shells. The characterization of the drug-loaded CSNPs were performed by FTIR, XRD, SEM and TEM analyses.
View Article and Find Full Text PDFCiprofloxacin hydrochloride-loaded ocular silk fibroin liposomes: Formulation, characterisation, cytotoxicity, and antimicrobial activity.
Heliyon
November 2024
Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Ocular drugs have low absorption because of the unique environment in the eye, making ocular drugs one of the most challenging pharmaceutical initiatives. Liposomes have shown to be a promising ocular drug delivery system over the years because of enhanced drug absorption, biocompatibility, and biodegradability. Utilising a mucoadhesive material alongside liposomes could be a promising strategy to increase the therapeutic efficacy of ocular drugs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!