Background: Sagging skin is one of the most concerning esthetic issues for elderly individuals. Although reduced skin elasticity has been reported as the cause of sagging skin, a loss of skin elasticity alone is insufficient to explain sagging facial skin. This study investigated the mechanisms underlying sagging skin, with a focus on the subcutaneous network of collagenous fibers known as the retinacula cutis (RC).
Methods: To evaluate the structure of the RC noninvasively, tomographic images of the face were obtained using magnetic resonance imaging (MRI). The RC was identified by comparing MRI results with histological specimens of human skin. A descriptive scale was used to evaluate the degree of sagging, and a device equipped with a 6-mm-diameter probe was used to measure the elasticity of deeper skin layers and evaluate the physical properties of the skin.
Results: The density of RC in subcutaneous tissue correlated negatively with sagging scores and positively with elasticity.
Conclusion: These results imply that a sparse RC structure contributes to a reduction in the elasticity of subcutaneous tissue, resulting in a greater degree of sagging facial skin. These findings are expected to contribute to the understanding of the mechanisms underlying sagging skin.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/srt.12395 | DOI Listing |
Int J Cosmet Sci
January 2025
Genomic Sciences and Biotechnology Program, Catholic University of Brasilia, Brasília, Federal District, Brazil.
Background: The aging of the skin, particularly around the periorbital region, is a complex process characterized by the accumulation of senescent cells, decreased collagen production, and reduced skin elasticity, leading to visible signs such as fine lines, wrinkles, and sagging.
Objective: This study investigates the efficacy of a novel topical formulation, OS-01 EYE, containing the senomorphic peptide, OS-01, along with other active ingredients, in improving the skin around the eyes.
Methods: A 12-week clinical study was conducted with 22 participants who applied OS-01 EYE twice daily.
Int J Cosmet Sci
January 2025
L'Oréal Research & Innovation, Chevilly-Larue, France.
Objective: To assess, clinically and instrumentally, the efficacy of a stabilized 12% Vitamin C (VC)-based serum (pH 6) on skin photoageing of women of various age and phototype.
Materials And Methods: Eighty women, with Phototypes I to VI, of various age (45-70y) living in Mauritius, participated in an open, uncontrolled study. After a two-week period of washout, they applied the Vitamin C-based serum twice a day for 2 months onto their whole face as well as a hydrating cream every evening to ensure a comparable skin hydration level in all subjects.
Cureus
December 2024
Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kawasaki, JPN.
Background: Recently, autologous cultured fibroblast and platelet-rich plasma (PRP) therapies have been attempted for skin rejuvenation. Unlike PRP, grafted fibroblasts not only produce connective tissue but also influence the surrounding environment through a paracrine effect. Fibroblast-derived cytokines interact with and are modulated by neighboring tissue-constituting cells.
View Article and Find Full Text PDFBackground: There is continuous demand for safe, effective cosmetic ingredients to treat the signs of aging skin, including fine lines, wrinkles, brown spots, discoloration, laxity, and sagging. While there are a plethora of cosmeceutical peptides, few combine anti-aging and anti-inflammatory benefits with small size.
Methods: Preclinical and clinical studies evaluated the anti-inflammatory properties, anti-aging benefits, and tolerability of acetyl dipeptide-31 amide (AP31), a novel, small, anti-aging micropeptide, to understand its impact as a multifaceted, cosmetic, anti-aging, and anti-inflammaging ingredient.
Aesthet Surg J
January 2025
Department of Dermatology, Erasmus Universiteit Rotterdam, Rotterdam, Netherlands.
Background: Midfacial aging involves skeletal changes, muscle weakening, and fat redistribution, resulting in volume loss, skin sagging, and deepened nasolabial folds. High-Intensity Facial Electrical Stimulation (HIFES) combined with Radiofrequency (RF) is a novel non-invasive method to address these changes by enhancing muscle mass and remodeling subcutaneous tissue.
Objectives: To assess the efficacy of HIFES and Synchronized RF in improving midfacial aesthetics, specifically muscle thickness, skin displacement, and facial volume.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!